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Spero Therapeutics, Inc.

SPRO Net buying
CIK 0001701108 #4540 in the set updated 21 Sep 2026
Bought (120 mo)
$44.50M
out of their own pocket, the only kind of buying there is
Sold (120 mo)
$17.95M
$115.47K on a plan · $1.18M straight out of an exercise
Sold at will
$16.66M
53 of 81 sales
Net
+$26.55M
+$27.84M against sales at will

By person

22 insiders · 115 transactions
Insider
Role
Bought
Sold
Net
Holding
Of company
Worth
Change
GSK plc entity
10% owner
$7.00M (2)
—
+$7.00M
3,788,012
6.50%
$9.51M
+104.3%
Aquilo Capital Management, LLC entity
10% owner
$22.41M (27)
$15.42M (13)
+$7.00M
11,513,987
19.77%
$28.90M
−8.6%
FORMELA JEAN FRANCOIS
Director
$6.00M (1)
—
+$6.00M
2,408,128
4.14%
$6.04M
+5,529%
Goyal Vikas
Director
$6.00M (1)
—
+$6.00M
1,854,006
3.18%
$4.65M
—
Breum Casper
Director
$3.00M (1)
—
+$3.00M
1,091,774
1.87%
$2.74M
—
Mahadevia Ankit
Director
—
$1.04M (28) scheduled
−$1.04M
703,294
1.21%
$1.77M
+968.6%
Rajavelu Esther
See Remarks
—
$475.99K (8)
−$475.99K
986,851
1.69%
$2.48M
—
Shukla Sath
CEO & President
—
$305.74K (12)
−$305.74K
1,736,883
2.98%
$4.36M
—
Larkin Cristina
Chief Operating Officer
$21.00K (1)
$298.00K (2) scheduled
−$277.00K
63,581
0.1092%
$159.59K
—
Keutzer Timothy
Chief Operating Officer
—
$246.39K (12)
−$246.39K
742,506
1.28%
$1.86M
+29,600%
HAMED KAMAL
Chief Medical Officer
—
$88.62K (2)
−$88.62K
788,117
1.35%
$1.98M
—
JOSEPH TAMARA L
Chief Legal Officer
—
$50.99K (3)
−$50.99K
531,615
0.9129%
$1.33M
—
Sendek Joel
Chief Financial Officer
$70.00K (1)
$35.00K (1) scheduled
+$35.00K
25,362
0.0436%
$63.66K
+149.1%
Zack Debra
Chief Medical Officer
—
—
—
162,311
0.2787%
$407.40K
—
Deshpande Milind
Director
—
—
—
101,454
0.1742%
$254.65K
+516.6%
Tregoning Kathleen
Director
—
—
—
85,000
0.1460%
$213.35K
—
Smith Cynthia
Director
—
—
—
85,000
0.1460%
$213.35K
—
THOMAS FRANK E
Director
—
—
—
85,000
0.1460%
$213.35K
—
Jackson Scott Thomas
Director
—
—
—
85,000
0.1460%
$213.35K
—
VINK PATRICK V.J.J.
Director
—
—
—
85,000
0.1460%
$213.35K
—
Pottage John C Jr
Director
—
—
—
85,000
0.1460%
$213.35K
—
Melnick David A.
Chief Medical Officer
—
—
—
62,081
0.1066%
$155.82K
—

Individual transactions

53
Insider
Date
Role
Action
Shares
Price
Amount
Rajavelu Esther
4 May 2026
See Remarks
Sell
25,240
$2.51
$63.35K
Keutzer Timothy
6 Feb 2026
Chief Operating Officer
Sell
18,652
$2.36
$44.02K
Rajavelu Esther
6 Feb 2026
See Remarks
Sell
50,816
$2.36
$119.93K
Rajavelu Esther
6 Feb 2026
See Remarks
Sell
37,101
$2.36
$87.56K
Keutzer Timothy
4 Feb 2026
Chief Operating Officer
Sell
3,471
$2.24
$7.78K
Keutzer Timothy
3 Feb 2026
Chief Operating Officer
Sell
24,224
$2.14
$51.84K
Rajavelu Esther
2 Feb 2026
See Remarks
Sell
18,442
$2.20
$40.57K
Keutzer Timothy
2 Feb 2026
Chief Operating Officer
Sell
18,891
$2.20
$41.56K
Rajavelu Esther
7 Nov 2025
See Remarks
Sell
40,270
$2.37
$95.44K
Keutzer Timothy
28 Aug 2025
Chief Operating Officer
Sell
1,695
$1.97
$3.34K
Mahadevia Ankit
28 Aug 2025
Director
Sell
6,572
$1.97
$12.95K
Mahadevia Ankit
5 Feb 2025
Director
Sell
55,260
$0.78
$43.10K
Mahadevia Ankit
5 Feb 2025
Director
Sell
13,959
$0.78
$10.89K
Shukla Sath
5 Feb 2025
CEO & President
Sell
106,408
$0.78
$83.00K
Shukla Sath
5 Feb 2025
CEO & President
Sell
42,786
$0.78
$33.37K
Shukla Sath
5 Feb 2025
CEO & President
Sell
6,139
$0.78
$4.79K
Rajavelu Esther
5 Feb 2025
CFO & CBO
Sell
20,689
$0.78
$16.14K
Keutzer Timothy
5 Feb 2025
Chief Operating Officer
Sell
24,920
$0.78
$19.44K
Keutzer Timothy
5 Feb 2025
Chief Operating Officer
Sell
27,643
$0.78
$21.56K
Keutzer Timothy
5 Feb 2025
Chief Operating Officer
Sell
3,974
$0.78
$3.10K
Rajavelu Esther
8 Nov 2024
CFO & CBO
Sell
17,245
$1.30
$22.42K
Rajavelu Esther
7 Nov 2024
CFO & CBO
Sell
23,351
$1.31
$30.59K
Shukla Sath
27 Aug 2024
CEO & President
Sell
2,757
$1.35
$3.72K
Keutzer Timothy
27 Aug 2024
Chief Operating Officer
Sell
2,213
$1.35
$2.99K
Mahadevia Ankit
27 Aug 2024
Director
Sell
5,912
$1.35
$7.98K
Shukla Sath
5 Aug 2024
CEO and President
Sell
17,641
$1.31
$23.11K
Shukla Sath
2 Aug 2024
CEO and President
Sell
14,800
$1.32
$19.54K
HAMED KAMAL
2 Feb 2024
Chief Medical Officer
Sell
28,075
$1.37
$38.46K
JOSEPH TAMARA L
2 Feb 2024
Chief Legal Officer
Sell
30,906
$1.37
$42.34K
Mahadevia Ankit
2 Feb 2024
Director
Sell
63,795
$1.37
$87.40K
Keutzer Timothy
2 Feb 2024
Chief Operating Officer
Sell
30,971
$1.36
$42.12K
HAMED KAMAL
13 Sep 2023
Chief Medical Officer
Sell
39,496
$1.27
$50.16K
Mahadevia Ankit
28 Aug 2023
Director
Sell
9,040
$1.26
$11.39K
JOSEPH TAMARA L
28 Aug 2023
Chief Legal Officer
Sell
1,854
$1.26
$2.34K
Keutzer Timothy
28 Aug 2023
Chief Development Officer
Sell
1,854
$1.26
$2.34K
Mahadevia Ankit
3 Feb 2023
CEO and President
Sell
12,286
$1.81
$22.24K
Shukla Sath
2 Feb 2023
Chief Financial Officer
Sell
9,504
$1.83
$17.37K
JOSEPH TAMARA L
2 Feb 2023
Chief Legal Officer
Sell
3,394
$1.86
$6.31K
Keutzer Timothy
2 Feb 2023
Chief Operating Officer
Sell
3,394
$1.86
$6.31K
Aquilo Capital Management, LLC
22 Sep 2022
10% owner
Sell indirect
566,284
$2.25
$1.27M
Aquilo Capital Management, LLC
22 Sep 2022
10% owner
Sell indirect
1,335,512
$2.25
$3.01M
Shukla Sath
29 Aug 2022
Chief Financial Officer
Sell
6,017
$0.89
$5.38K
Aquilo Capital Management, LLC
8 Feb 2021
10% owner
Sell indirect
3,000
$21.74
$65.22K
Aquilo Capital Management, LLC
4 Feb 2021
10% owner
Sell indirect
34,144
$18.99
$648.25K
Aquilo Capital Management, LLC
3 Feb 2021
10% owner
Sell indirect
29,354
$18.98
$557.10K
Aquilo Capital Management, LLC
2 Feb 2021
10% owner
Sell indirect
22,841
$18.99
$433.77K
Aquilo Capital Management, LLC
1 Feb 2021
10% owner
Sell indirect
13,661
$19.24
$262.86K
Aquilo Capital Management, LLC
17 Dec 2020
10% owner
Sell indirect
250,000
$18.81
$4.70M
Aquilo Capital Management, LLC
16 Dec 2020
10% owner
Sell indirect
14,933
$18.62
$278.03K
Aquilo Capital Management, LLC
9 Nov 2020
10% owner
Sell indirect
125,900
$13.77
$1.73M
Aquilo Capital Management, LLC
6 Nov 2020
10% owner
Sell indirect
5,000
$13.77
$68.87K
Aquilo Capital Management, LLC
5 Nov 2020
10% owner
Sell indirect
96,600
$13.98
$1.35M
Aquilo Capital Management, LLC
4 Nov 2020
10% owner
Sell indirect
72,500
$14.26
$1.03M
Show all 115 transactions →

What was left out

Form 4 filings counted 197
Amendments (4/A) skipped 0
Filings about a different issuer 0
Unreadable filings 0
Joint filings 23
Sales on a Rule 10b5-1 plan 4
Sales straight out of an exercise 24
Sales at will 53
Transactions with no price 0
Shares from compensation/vesting 13,007,082
Sales filed before the plan box existed 18
History held since 7 Nov 2017