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IONIS PHARMACEUTICALS INC

IONS Net selling
CIK 0000874015 #948 in the set updated 17 Sep 2026
Bought (120 mo)
$1.72M
out of their own pocket, the only kind of buying there is
Sold (120 mo)
$333.35M
$30.44M on a plan · $245.85M straight out of an exercise
Sold at will
$57.07M
189 of 627 sales
Net
−$331.63M
−$55.35M against sales at will

By person

28 insiders · 648 transactions
11.9×

Brett P. Monia holds 11.9 times base salary in stock. $12.53M of shares against $1.05M in salary for 2025.

Salary from the company's own proxy. The shares are what Brett P. Monia last reported holding, valued at $51.60, the price Common Stock was last bought or sold at on the open market here, on 31 Jul 2026.

Insider
Role
Bought
Sold
Net
Holding
Of company
Worth
Change
Monia Brett P
Chief Executive Officer
—
$60.06M (60) scheduled
−$60.06M
242,760
0.1461%
$12.53M
+3,096%
CROOKE STANLEY T
Exec Chairman of the Board
—
$46.32M (113) scheduled
−$46.32M
1,202,384
0.7235%
$62.04M
−14.1%
BENNETT C FRANK
EVP, Chief Scientific Officer
—
$30.87M (45) scheduled
−$30.87M
60,128
0.0362%
$3.10M
+281.3%
O'NEIL PATRICK R.
EVP CLO & General Counsel
—
$30.65M (81) scheduled
−$30.65M
59,205
0.0356%
$3.05M
+523.7%
HOUGEN ELIZABETH L
EVP, Finance & CFO
—
$27.53M (36) scheduled
−$27.53M
82,660
0.0497%
$4.27M
+1,170%
Geary Richard S
EVP, Chief Development Officer
—
$23.43M (43) scheduled
−$23.43M
59,657
0.0359%
$3.08M
+603.3%
PARSHALL B LYNNE
Director
—
$17.35M (33) scheduled
−$17.35M
51,344
0.0309%
$2.65M
+207.6%
KLEIN JOSEPH III
Director
—
$12.81M (50) scheduled
−$12.81M
11,014
0.0066%
$568.32K
+43.8%
Swayze Eric
EVP Research
—
$11.07M (31) scheduled
−$11.07M
22,077
0.0133%
$1.14M
+2,904%
WENDER JOSEPH H
Director
—
$10.14M (17) scheduled
−$10.14M
52,035
0.0313%
$2.69M
−15.8%
Devers Shannon L.
EVP, Chief Human Resources Ofc
—
$8.99M (16) scheduled
−$8.99M
16,348
0.0098%
$843.56K
+106.7%
LOSCALZO JOSEPH
Director
—
$8.56M (7) scheduled
−$8.56M
36,330
0.0219%
$1.87M
+654.7%
Schneider Eugene
EVP, Chf Clinical Develop Ofcr
—
$7.94M (15) scheduled
−$7.94M
77,114
0.0464%
$3.98M
+192.0%
Baroldi Joseph
EVP, Chief Business Officer
—
$7.09M (25) scheduled
−$7.09M
49,578
0.0298%
$2.56M
+1,065%
Diaz Allene M.
Director
—
$5.39M (8) scheduled
−$5.39M
3,811
0.0023%
$196.65K
—
BERTHELSEN SPENCER R
Director
—
$4.88M (9) scheduled
−$4.88M
161,233
0.0970%
$8.32M
+103.2%
Kordasiewicz Holly B.
EVP, Chief Development Officer
—
$4.81M (4) scheduled
−$4.81M
22,096
0.0133%
$1.14M
+42.7%
Birchler Brian
EVP, Corp and Development Ops
—
$4.04M (11) scheduled
−$4.04M
102,883
0.0619%
$5.31M
+45.6%
Jenne Kyle
EVP, Chf GL Pdt Str Ofcr
—
$3.42M (5) scheduled
−$3.42M
23,713
0.0143%
$1.22M
+1,092%
MUTO FREDERICK T
Director
—
$3.37M (7) scheduled
−$3.37M
59,597
0.0359%
$3.08M
+713.6%
HERMAN JOAN E
Director
—
$3.17M (2) scheduled
−$3.17M
51,306
0.0309%
$2.65M
—
Hayden Michael R
Director
$1.72M (5)
—
+$1.72M
78,298
0.0471%
$4.04M
+1,857%
Cadoret-Manier Onaiza
EVP, Chf GL Pdt Str & Oper Ofc
—
$687.39K (5)
−$687.39K
35,825
0.0216%
$1.85M
—
Castleman Breaux
Director
—
$600.00K (1) scheduled
−$600.00K
19,183
0.0115%
$989.84K
+110.6%
Boyce Sarah
Chief Business Officer
—
$176.67K (3)
−$176.67K
8,931
0.0054%
$460.84K
+317.7%
Reikes Peter N
Director
—
—
—
14,222
0.0086%
$733.86K
—
YANG MICHAEL J.
Director
—
—
—
7,940
0.0048%
$409.70K
—
McDevitt Damien
Chief Business Officer
—
—
—
2,573
0.0015%
$132.77K
—

Individual transactions

112
Insider
Date
Role
Action
Shares
Price
Amount
Diaz Allene M.
7 Jul 2026
Director
Sold after exercise
10,111
$85.42
$863.64K
KLEIN JOSEPH III
1 Jul 2026
Director
Sold after exercise
11,419
$79.04
$902.55K
KLEIN JOSEPH III
1 Jul 2026
Director
Sold after exercise
99
$79.45
$7.87K
Monia Brett P
26 Jun 2026
Chief Executive Officer
Sold after exercise
50,000
$80.59
$4.03M
Schneider Eugene
26 Jun 2026
EVP, Chf Clinical Develop Ofcr
Sold after exercise
26,000
$81.05
$2.11M
Baroldi Joseph
26 Jun 2026
EVP, Chief Business Officer
Sold after exercise indirect
5,635
$80.16
$451.70K
Monia Brett P
25 Jun 2026
Chief Executive Officer
Sold after exercise
21,072
$78.49
$1.65M
Monia Brett P
24 Jun 2026
Chief Executive Officer
Sold after exercise
14,565
$78.41
$1.14M
BERTHELSEN SPENCER R
15 Jun 2026
Director
Sold after exercise
8,000
$73.49
$587.92K
Kordasiewicz Holly B.
12 Jun 2026
EVP, Chief Development Officer
Sold after exercise
19,842
$74.05
$1.47M
Kordasiewicz Holly B.
12 Jun 2026
EVP, Chief Development Officer
Sold after exercise
41,004
$73.09
$3.00M
BERTHELSEN SPENCER R
1 Jun 2026
Director
Sold after exercise
8,000
$75.67
$605.36K
Monia Brett P
14 May 2026
Chief Executive Officer
Sold after exercise
3,220
$78.68
$253.35K
Monia Brett P
13 May 2026
Chief Executive Officer
Sold after exercise
1,316
$78.01
$102.67K
LOSCALZO JOSEPH
4 May 2026
Director
Sold after exercise
17,781
$75.58
$1.34M
LOSCALZO JOSEPH
4 May 2026
Director
Sold after exercise
59,508
$74.90
$4.46M
KLEIN JOSEPH III
1 May 2026
Director
Sold after exercise
1,431
$74.45
$106.53K
KLEIN JOSEPH III
1 May 2026
Director
Sold after exercise
8,680
$73.35
$636.70K
KLEIN JOSEPH III
1 Apr 2026
Director
Sold after exercise
2,216
$75.95
$168.31K
KLEIN JOSEPH III
1 Apr 2026
Director
Sold after exercise
20,105
$75.50
$1.52M
HOUGEN ELIZABETH L
16 Mar 2026
EVP, Finance & CFO
Sold after exercise
9,440
$72.77
$686.90K
HOUGEN ELIZABETH L
16 Mar 2026
EVP, Finance & CFO
Sold after exercise
205,608
$72.38
$14.88M
Jenne Kyle
10 Mar 2026
EVP, Chf GL Pdt Str Ofcr
Sold after exercise
16,086
$76.30
$1.23M
Jenne Kyle
10 Mar 2026
EVP, Chf GL Pdt Str Ofcr
Sold after exercise
21,191
$75.50
$1.60M
Monia Brett P
10 Mar 2026
Chief Executive Officer
Sold after exercise
17,591
$76.34
$1.34M
Monia Brett P
10 Mar 2026
Chief Executive Officer
Sold after exercise
16,512
$75.47
$1.25M
Monia Brett P
9 Mar 2026
Chief Executive Officer
Sold after exercise
1,684
$75.58
$127.28K
Monia Brett P
9 Mar 2026
Chief Executive Officer
Sold after exercise
117,604
$75.26
$8.85M
Monia Brett P
9 Mar 2026
Chief Executive Officer
Sold after exercise
7,382
$74.11
$547.09K
Baroldi Joseph
4 Mar 2026
EVP, Chief Business Officer
Sold after exercise indirect
201
$80.00
$16.08K
Baroldi Joseph
4 Mar 2026
EVP, Chief Business Officer
Sold after exercise indirect
238
$80.00
$19.04K
LOSCALZO JOSEPH
4 Mar 2026
Director
Sold after exercise
200
$80.00
$16.00K
Baroldi Joseph
3 Mar 2026
EVP, Chief Business Officer
Sold after exercise indirect
36
$81.01
$2.92K
Baroldi Joseph
3 Mar 2026
EVP, Chief Business Officer
Sold after exercise indirect
2,088
$80.41
$167.89K
Baroldi Joseph
3 Mar 2026
EVP, Chief Business Officer
Sold after exercise
4,096
$79.36
$325.06K
BENNETT C FRANK
3 Mar 2026
EVP, Chief Scientific Officer
Sold after exercise
802
$80.76
$64.77K
BENNETT C FRANK
3 Mar 2026
EVP, Chief Scientific Officer
Sold after exercise
12,687
$79.88
$1.01M
BENNETT C FRANK
3 Mar 2026
EVP, Chief Scientific Officer
Sold after exercise
71,600
$79.10
$5.66M
Devers Shannon L.
3 Mar 2026
EVP, Chief Human Resources Ofc
Sold after exercise
755
$80.84
$61.03K
Devers Shannon L.
3 Mar 2026
EVP, Chief Human Resources Ofc
Sold after exercise
5,030
$80.00
$402.39K
Devers Shannon L.
3 Mar 2026
EVP, Chief Human Resources Ofc
Sold after exercise
14,321
$79.12
$1.13M
Diaz Allene M.
3 Mar 2026
Director
Sold after exercise
1,005
$80.80
$81.20K
Diaz Allene M.
3 Mar 2026
Director
Sold after exercise
14,608
$79.88
$1.17M
Diaz Allene M.
3 Mar 2026
Director
Sold after exercise
39,265
$79.11
$3.11M
KLEIN JOSEPH III
3 Mar 2026
Director
Sold after exercise
1,012
$80.82
$81.79K
KLEIN JOSEPH III
3 Mar 2026
Director
Sold after exercise
6,794
$80.00
$543.49K
KLEIN JOSEPH III
3 Mar 2026
Director
Sold after exercise
13,526
$79.17
$1.07M
LOSCALZO JOSEPH
3 Mar 2026
Director
Sold after exercise
832
$80.33
$66.83K
BENNETT C FRANK
2 Feb 2026
EVP, Chief Scientific Officer
Sold after exercise
16,463
$83.03
$1.37M
BENNETT C FRANK
2 Feb 2026
EVP, Chief Scientific Officer
Sold after exercise
48,626
$83.03
$4.04M
BENNETT C FRANK
2 Feb 2026
EVP, Chief Scientific Officer
Sold after exercise
20,000
$82.60
$1.65M
Devers Shannon L.
7 Jan 2026
EVP, Chief Human Resources Ofc
Sold after exercise
9,264
$84.62
$783.92K
Devers Shannon L.
7 Jan 2026
EVP, Chief Human Resources Ofc
Sold after exercise
3,829
$84.62
$324.01K
Devers Shannon L.
7 Jan 2026
EVP, Chief Human Resources Ofc
Sold after exercise
3,460
$84.62
$292.79K
Devers Shannon L.
7 Jan 2026
EVP, Chief Human Resources Ofc
Sold after exercise
2,101
$85.36
$179.34K
Devers Shannon L.
7 Jan 2026
EVP, Chief Human Resources Ofc
Sold after exercise
25,545
$85.36
$2.18M
Swayze Eric
2 Jan 2026
EVP Research
Sold after exercise
18,338
$79.27
$1.45M
Swayze Eric
2 Jan 2026
EVP Research
Sold after exercise
5,125
$78.57
$402.67K
Devers Shannon L.
25 Nov 2025
EVP, Chief Human Resources Ofc
Sold after exercise
16,777
$80.91
$1.36M
KLEIN JOSEPH III
25 Nov 2025
Director
Sold after exercise indirect
4,000
$80.00
$320.00K
KLEIN JOSEPH III
25 Nov 2025
Director
Sold after exercise indirect
4,000
$80.00
$320.00K
KLEIN JOSEPH III
25 Nov 2025
Director
Sold after exercise indirect
4,000
$80.00
$320.00K
HERMAN JOAN E
19 Nov 2025
Director
Sold after exercise
32,000
$72.13
$2.31M
HERMAN JOAN E
19 Nov 2025
Director
Sold after exercise
12,000
$72.13
$865.59K
Geary Richard S
6 Nov 2025
EVP, Chief Development Officer
Sold after exercise
18,300
$75.42
$1.38M
Geary Richard S
6 Nov 2025
EVP, Chief Development Officer
Sold after exercise
14,738
$76.10
$1.12M
Geary Richard S
5 Nov 2025
EVP, Chief Development Officer
Sold after exercise
801
$75.01
$60.08K
Geary Richard S
5 Nov 2025
EVP, Chief Development Officer
Sold after exercise
800
$75.01
$60.01K
Geary Richard S
3 Nov 2025
EVP, Chief Development Officer
Sold after exercise
905
$75.05
$67.92K
Geary Richard S
3 Nov 2025
EVP, Chief Development Officer
Sold after exercise
775
$75.05
$58.17K
Geary Richard S
31 Oct 2025
EVP, Chief Development Officer
Sold after exercise
20,000
$75.11
$1.50M
Geary Richard S
31 Oct 2025
EVP, Chief Development Officer
Sold after exercise
34,664
$75.11
$2.60M
Geary Richard S
31 Oct 2025
EVP, Chief Development Officer
Sold after exercise
34,585
$75.11
$2.60M
LOSCALZO JOSEPH
31 Oct 2025
Director
Sold after exercise
16,000
$75.10
$1.20M
Birchler Brian
15 Oct 2025
EVP, Corp and Development Ops
Sold after exercise
12,425
$72.23
$897.40K
Devers Shannon L.
15 Oct 2025
EVP, Chief Human Resources Ofc
Sold after exercise
6,000
$72.94
$437.65K
Birchler Brian
14 Oct 2025
EVP, Corp and Development Ops
Sold after exercise
11,475
$72.03
$826.59K
O'NEIL PATRICK R.
6 Oct 2025
EVP CLO & General Counsel
Sold after exercise
3,241
$69.27
$224.49K
O'NEIL PATRICK R.
6 Oct 2025
EVP CLO & General Counsel
Sold after exercise
10,200
$69.89
$712.85K
Baroldi Joseph
2 Oct 2025
EVP, Chief Business Officer
Sold after exercise
15,000
$68.01
$1.02M
O'NEIL PATRICK R.
2 Oct 2025
EVP CLO & General Counsel
Sold after exercise
34,461
$67.69
$2.33M
O'NEIL PATRICK R.
2 Oct 2025
EVP CLO & General Counsel
Sold after exercise
30,203
$67.69
$2.04M
Swayze Eric
2 Oct 2025
EVP Research
Sold after exercise
12,972
$66.23
$859.08K
Swayze Eric
1 Oct 2025
EVP Research
Sold after exercise
14,142
$66.09
$934.66K
HOUGEN ELIZABETH L
30 Sep 2025
EVP, Finance & CFO
Sold after exercise
49,800
$65.26
$3.25M
Geary Richard S
30 Sep 2025
EVP, Chief Development Officer
Sold after exercise
57,900
$65.24
$3.78M
O'NEIL PATRICK R.
30 Sep 2025
EVP CLO & General Counsel
Sold after exercise
14,827
$64.68
$958.98K
O'NEIL PATRICK R.
29 Sep 2025
EVP CLO & General Counsel
Sold after exercise
10,473
$64.54
$675.95K
O'NEIL PATRICK R.
12 Sep 2025
EVP CLO & General Counsel
Sold after exercise
1,700
$64.58
$109.79K
O'NEIL PATRICK R.
9 Sep 2025
EVP CLO & General Counsel
Sold after exercise
1,000
$64.56
$64.56K
O'NEIL PATRICK R.
9 Sep 2025
EVP CLO & General Counsel
Sold after exercise
20,000
$64.56
$1.29M
Baroldi Joseph
9 Sep 2025
EVP, Chief Business Officer
Sold after exercise
11,950
$62.16
$742.84K
Baroldi Joseph
5 Sep 2025
EVP, Chief Business Officer
Sold after exercise
250
$62.00
$15.50K
Schneider Eugene
3 Sep 2025
EVP, Chf Clinical Develop Ofcr
Sold after exercise
7,203
$61.42
$442.38K
Schneider Eugene
3 Sep 2025
EVP, Chf Clinical Develop Ofcr
Sold after exercise
12,455
$60.46
$753.04K
LOSCALZO JOSEPH
3 Sep 2025
Director
Sold after exercise
16,000
$60.15
$962.37K
BENNETT C FRANK
3 Sep 2025
EVP, Chief Scientific Officer
Sold after exercise
33,909
$60.62
$2.06M
O'NEIL PATRICK R.
3 Sep 2025
EVP CLO & General Counsel
Sold after exercise
11,375
$61.42
$698.65K
O'NEIL PATRICK R.
3 Sep 2025
EVP CLO & General Counsel
Sold after exercise
65,475
$60.89
$3.99M
Baroldi Joseph
3 Sep 2025
EVP, Chief Business Officer
Sold after exercise
30,000
$59.09
$1.77M
Baroldi Joseph
3 Sep 2025
EVP, Chief Business Officer
Sold after exercise
2,800
$62.01
$173.63K
Devers Shannon L.
3 Sep 2025
EVP, Chief Human Resources Ofc
Sold after exercise
3,162
$61.02
$192.94K
KLEIN JOSEPH III
3 Sep 2025
Director
Sold after exercise indirect
28,000
$60.00
$1.68M
KLEIN JOSEPH III
3 Sep 2025
Director
Sold after exercise indirect
28,000
$60.00
$1.68M
Monia Brett P
3 Sep 2025
Chief Executive Officer
Sold after exercise
59,699
$61.06
$3.65M
Monia Brett P
3 Sep 2025
Chief Executive Officer
Sold after exercise
127,500
$60.13
$7.67M
Monia Brett P
3 Sep 2025
Chief Executive Officer
Sold after exercise
16,615
$59.12
$982.26K
O'NEIL PATRICK R.
2 Sep 2025
EVP CLO & General Counsel
Sold after exercise
13,050
$54.51
$711.42K
BENNETT C FRANK
18 Aug 2025
EVP, Chief Scientific Officer
Sold after exercise
10,000
$43.98
$439.78K
Monia Brett P
30 Jul 2025
Chief Executive Officer
Sold after exercise
2,432
$45.00
$109.44K
KLEIN JOSEPH III
16 Jul 2024
Director
Sold after exercise indirect
12,000
$50.00
$600.00K
BERTHELSEN SPENCER R
17 Jun 2024
Director
Sold after exercise
16,000
$40.29
$644.64K
Showing 250 of 648 transactions. The figures above use every one of them.

What was left out

Form 4 filings counted 788
Amendments (4/A) skipped 23
Filings about a different issuer 7
Unreadable filings 0
Joint filings 0
Sales on a Rule 10b5-1 plan 82
Sales straight out of an exercise 356
Sales at will 189
Transactions with no price 0
Shares from compensation/vesting 6,790,966
Sales filed before the plan box existed 115
History held since 6 Sep 2016