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Prelude Therapeutics Inc

PRLD Net buying
CIK 0001678660 #3089 in the set updated 17 Sep 2026
Bought (120 mo)
$113.56M
out of their own pocket, the only kind of buying there is
Sold (120 mo)
$10.40M
$0.00 on a plan · $10.32M straight out of an exercise
Sold at will
$81.27K
1 of 67 sales
Net
+$103.16M
+$113.48M against sales at will

By person

16 insiders · 111 transactions
Insider
Role
Bought
Sold
Net
Holding
Of company
Worth
Change
Bonita David P
Director
$41.00M (5)
—
+$41.00M
10,376,317
13.00%
$46.07M
—
ORBIMED ADVISORS LLC entity
Director
$41.00M (5)
—
+$41.00M
10,376,317
13.00%
$46.07M
—
BAKER BROS. ADVISORS LP entity
Director
$30.00M (2)
—
+$30.00M
9,252,951
11.59%
$41.08M
—
Mauro David J
Chief Medical Officer
—
$5.61M (30) scheduled
−$5.61M
0
0.0000%
$0.00
—
Scherle Peggy
Chief Scientific Officer
—
$2.26M (17) scheduled
−$2.26M
172,920
0.2167%
$767.76K
0.0%
Morosini Deborah
EVP, Chief of Clinical Affairs
$8.44K (1)
$1.00M (6) scheduled
−$995.75K
444
0.0006%
$1.97K
—
Vaddi Krishna
CEO
$873.73K (15)
—
+$873.73K
2,666,981
3.34%
$11.84M
+77.2%
Pierce Christopher
EVP and Chief of Business Oper
$71.25K (1)
$882.45K (6) scheduled
−$811.20K
3,750
0.0047%
$16.65K
—
Piper Brian
Chief Financial Officer
—
$563.36K (7) scheduled
−$563.36K
0
0.0000%
$0.00
—
Combs Andrew
Chief Chemistry Officer
$268.67K (6)
—
+$268.67K
480,123
0.6016%
$2.13M
+76.5%
Dier Mardi
Director
$190.00K (1)
—
+$190.00K
10,000
0.0125%
$44.40K
—
Chardonnet Laurent
Chief Financial Officer
$117.40K (3)
—
+$117.40K
42,165
0.0528%
$187.21K
+644.3%
Huang Jane
President, CMO
—
$81.27K (1)
−$81.27K
86,917
0.1089%
$385.91K
—
Lim Bryant David
CLO, CFO, Corp Sec.
$35.57K (2)
—
+$35.57K
27,400
0.0343%
$121.66K
—
RA CAPITAL MANAGEMENT, L.P. entity
10% owner
—
—
—
6,475,882
8.11%
$28.75M
−17.8%
FRIEDMAN PAUL A
Director
—
—
—
500,098
0.6267%
$2.22M
+866.8%

Individual transactions

111
Insider
Date
Role
Action
Shares
Price
Amount
ORBIMED ADVISORS LLC
21 Apr 2026
Director
Buy indirect
1,126,126
$4.44
$5.00M
ORBIMED ADVISORS LLC
21 Apr 2026
Director
Buy indirect
1,689,189
$4.44
$7.50M
Bonita David P
21 Apr 2026
Director
Buy indirect
1,126,126
$4.44
$5.00M
Bonita David P
21 Apr 2026
Director
Buy indirect
1,689,189
$4.44
$7.50M
Vaddi Krishna
25 Mar 2025
CEO
Buy
675,000
$0.69
$467.44K
Combs Andrew
25 Mar 2025
Chief Chemistry Officer
Buy
100,000
$0.69
$69.25K
Vaddi Krishna
21 Mar 2025
CEO
Buy
15,000
$0.73
$10.96K
Vaddi Krishna
20 Mar 2025
CEO
Buy
5,416
$0.73
$3.95K
Vaddi Krishna
17 Mar 2025
CEO
Buy
9,106
$0.75
$6.83K
Vaddi Krishna
14 Mar 2025
CEO
Buy
29,999
$0.75
$22.63K
Vaddi Krishna
13 Mar 2025
CEO
Buy
50,000
$0.72
$35.82K
Vaddi Krishna
12 Mar 2025
CEO
Buy
47,500
$0.71
$33.74K
Vaddi Krishna
31 Dec 2024
CEO
Buy indirect
5,000
$1.21
$6.04K
Vaddi Krishna
30 Dec 2024
CEO
Buy indirect
10,000
$1.20
$12.00K
Combs Andrew
23 Dec 2024
Chief Chemistry Officer
Buy
60,000
$1.37
$82.00K
Combs Andrew
20 Dec 2024
Chief Chemistry Officer
Buy
3,075
$1.15
$3.54K
Vaddi Krishna
19 Dec 2024
CEO
Buy indirect
6,888
$0.89
$6.12K
Lim Bryant David
19 Dec 2024
CLO, Interim CFO, Corp Sec.
Buy
25,000
$0.91
$22.64K
Vaddi Krishna
18 Dec 2024
CEO
Buy
100,000
$0.93
$93.21K
Vaddi Krishna
25 May 2023
CEO
Buy
900
$5.31
$4.78K
Lim Bryant David
24 May 2023
Chief Legal Officer, Corp Sec.
Buy
2,400
$5.39
$12.94K
Vaddi Krishna
24 May 2023
CEO
Buy
1,000
$5.01
$5.01K
Vaddi Krishna
23 May 2023
CEO
Buy
11,856
$5.63
$66.75K
Chardonnet Laurent
23 May 2023
Chief Financial Officer
Buy
5,000
$5.50
$27.50K
Bonita David P
22 May 2023
Director
Buy indirect
869,565
$5.75
$5.00M
ORBIMED ADVISORS LLC
22 May 2023
Director
Buy indirect
869,565
$5.75
$5.00M
Huang Jane
6 Apr 2023
President, CMO
Sell
13,280
$6.12
$81.27K
Vaddi Krishna
20 Dec 2022
CEO
Buy indirect
19,188
$5.13
$98.45K
Chardonnet Laurent
8 Dec 2022
Chief Financial Officer
Buy
10,000
$4.76
$47.60K
Chardonnet Laurent
1 Jun 2022
Chief Financial Officer
Buy
10,000
$4.23
$42.30K
Combs Andrew
31 Mar 2022
EVP, Head of Chemistry
Exercised, kept
36,062
$1.89
$68.16K
Morosini Deborah
15 Dec 2021
EVP, Chief of Clinical Affairs
Sold after exercise
28,751
$13.00
$373.76K
Combs Andrew
14 Dec 2021
EVP, Head of Chemistry
Buy
4,000
$11.60
$46.40K
Combs Andrew
13 Dec 2021
EVP, Head of Chemistry
Buy
4,000
$12.12
$48.48K
Morosini Deborah
16 Nov 2021
EVP, Chief of Clinical Affairs
Sold after exercise
400
$16.43
$6.57K
Morosini Deborah
16 Nov 2021
EVP, Chief of Clinical Affairs
Sold after exercise
28,351
$15.87
$449.96K
Mauro David J
5 Oct 2021
Chief Medical Officer
Sold after exercise
1,289
$32.06
$41.33K
Mauro David J
5 Oct 2021
Chief Medical Officer
Sold after exercise
7,803
$31.30
$244.26K
Mauro David J
5 Oct 2021
Chief Medical Officer
Sold after exercise
5,908
$30.26
$178.76K
Mauro David J
7 Sep 2021
Chief Medical Officer
Sold after exercise
4,640
$37.79
$175.33K
Mauro David J
7 Sep 2021
Chief Medical Officer
Sold after exercise
2,873
$36.92
$106.08K
Mauro David J
7 Sep 2021
Chief Medical Officer
Sold after exercise
7,487
$35.91
$268.87K
Pierce Christopher
2 Sep 2021
EVP and Chief of Business Oper
Sold after exercise
6,930
$42.50
$294.51K
Pierce Christopher
2 Sep 2021
EVP and Chief of Business Oper
Sold after exercise
6,727
$41.52
$279.29K
Pierce Christopher
2 Sep 2021
EVP and Chief of Business Oper
Sold after exercise
3,343
$40.29
$134.70K
Scherle Peggy
27 Aug 2021
Chief Scientific Officer
Sold after exercise
607
$37.08
$22.51K
Scherle Peggy
27 Aug 2021
Chief Scientific Officer
Sold after exercise
2,707
$36.23
$98.09K
Scherle Peggy
27 Aug 2021
Chief Scientific Officer
Sold after exercise
2,700
$35.32
$95.38K
Scherle Peggy
26 Aug 2021
Chief Scientific Officer
Sold after exercise
1,700
$35.19
$59.82K
Piper Brian
25 Aug 2021
Chief Financial Officer
Sold after exercise
2,344
$34.33
$80.47K
Piper Brian
25 Aug 2021
Chief Financial Officer
Sold after exercise
3,889
$33.23
$129.23K
Piper Brian
25 Aug 2021
Chief Financial Officer
Sold after exercise
2,100
$32.44
$68.12K
Scherle Peggy
13 Aug 2021
Chief Scientific Officer
Sold after exercise
2,286
$35.07
$80.16K
Mauro David J
5 Aug 2021
Chief Medical Officer
Sold after exercise
100
$32.63
$3.26K
Mauro David J
5 Aug 2021
Chief Medical Officer
Sold after exercise
6,721
$32.15
$216.05K
Mauro David J
5 Aug 2021
Chief Medical Officer
Sold after exercise
2,063
$31.03
$64.01K
Mauro David J
5 Aug 2021
Chief Medical Officer
Sold after exercise
6,116
$29.93
$183.07K
Scherle Peggy
27 Jul 2021
Chief Scientific Officer
Sold after exercise
680
$36.09
$24.54K
Scherle Peggy
27 Jul 2021
Chief Scientific Officer
Sold after exercise
19,320
$35.45
$684.84K
Mauro David J
6 Jul 2021
Chief Medical Officer
Sold after exercise
300
$28.84
$8.65K
Mauro David J
6 Jul 2021
Chief Medical Officer
Sold after exercise
4,255
$28.13
$119.71K
Mauro David J
6 Jul 2021
Chief Medical Officer
Sold after exercise
10,445
$27.17
$283.74K
Mauro David J
7 Jun 2021
Chief Medical Officer
Sold after exercise
12,700
$32.73
$415.66K
Mauro David J
7 Jun 2021
Chief Medical Officer
Sold after exercise
900
$31.62
$28.46K
Mauro David J
7 Jun 2021
Chief Medical Officer
Sold after exercise
1,400
$30.35
$42.50K
Piper Brian
25 May 2021
Chief Financial Officer
Sold after exercise
399
$36.09
$14.40K
Piper Brian
25 May 2021
Chief Financial Officer
Sold after exercise
1,736
$35.45
$61.54K
Piper Brian
25 May 2021
Chief Financial Officer
Sold after exercise
3,088
$34.11
$105.34K
Piper Brian
25 May 2021
Chief Financial Officer
Sold after exercise
3,110
$33.53
$104.26K
Scherle Peggy
7 May 2021
Chief Scientific Officer
Sold after exercise
200
$41.85
$8.37K
Scherle Peggy
7 May 2021
Chief Scientific Officer
Sold after exercise
5,836
$41.14
$240.09K
Scherle Peggy
7 May 2021
Chief Scientific Officer
Sold after exercise
3,964
$40.30
$159.73K
Mauro David J
5 May 2021
Chief Medical Officer
Sold after exercise
1,109
$41.07
$45.54K
Mauro David J
5 May 2021
Chief Medical Officer
Sold after exercise
10,476
$40.30
$422.15K
Mauro David J
5 May 2021
Chief Medical Officer
Sold after exercise
3,415
$39.36
$134.40K
Morosini Deborah
29 Apr 2021
EVP, Chief of Clinical Affairs
Sold after exercise
3,223
$40.29
$129.85K
Pierce Christopher
29 Apr 2021
EVP and Chief of Business Oper
Sold after exercise
3,295
$40.29
$132.76K
Mauro David J
27 Apr 2021
Chief Medical Officer
Sold after exercise
1,711
$36.11
$61.79K
Mauro David J
27 Apr 2021
Chief Medical Officer
Sold after exercise
15,601
$35.68
$556.58K
Mauro David J
27 Apr 2021
Chief Medical Officer
Sold after exercise
7,688
$34.66
$266.48K
Mauro David J
19 Apr 2021
Chief Medical Officer
Sold after exercise
4,000
$31.27
$125.08K
Mauro David J
19 Apr 2021
Chief Medical Officer
Sold after exercise
21,000
$30.82
$647.27K
Mauro David J
8 Apr 2021
Chief Medical Officer
Sold after exercise
3,549
$39.56
$140.39K
Mauro David J
8 Apr 2021
Chief Medical Officer
Sold after exercise
1,293
$39.00
$50.42K
Mauro David J
8 Apr 2021
Chief Medical Officer
Sold after exercise
1,501
$37.83
$56.78K
Mauro David J
8 Apr 2021
Chief Medical Officer
Sold after exercise
3,274
$37.04
$121.26K
Morosini Deborah
8 Apr 2021
EVP, Chief of Clinical Affairs
Sold after exercise
100
$40.00
$4.00K
Pierce Christopher
8 Apr 2021
EVP and Chief of Business Oper
Sold after exercise
200
$40.00
$8.00K
Scherle Peggy
8 Apr 2021
Chief Scientific Officer
Sold after exercise
1,669
$39.57
$66.04K
Scherle Peggy
8 Apr 2021
Chief Scientific Officer
Sold after exercise
669
$38.97
$26.07K
Scherle Peggy
8 Apr 2021
Chief Scientific Officer
Sold after exercise
875
$37.72
$33.00K
Scherle Peggy
8 Apr 2021
Chief Scientific Officer
Sold after exercise
1,417
$36.97
$52.39K
Mauro David J
7 Apr 2021
Chief Medical Officer
Sold after exercise
7,083
$39.69
$281.12K
Mauro David J
7 Apr 2021
Chief Medical Officer
Sold after exercise
8,300
$39.03
$323.91K
Morosini Deborah
7 Apr 2021
EVP, Chief of Clinical Affairs
Sold after exercise
1,000
$40.04
$40.04K
Pierce Christopher
7 Apr 2021
EVP and Chief of Business Oper
Sold after exercise
828
$40.08
$33.19K
Scherle Peggy
7 Apr 2021
Chief Scientific Officer
Sold after exercise
200
$40.30
$8.06K
Scherle Peggy
7 Apr 2021
Chief Scientific Officer
Sold after exercise
6,881
$39.63
$272.68K
Scherle Peggy
7 Apr 2021
Chief Scientific Officer
Sold after exercise
8,289
$39.02
$323.41K
BAKER BROS. ADVISORS LP
27 Jan 2021
Director
Exercised, kept indirect
5,188
$12.85
$66.67K
BAKER BROS. ADVISORS LP
27 Jan 2021
Director
Exercised, kept indirect
5,188
$12.85
$66.67K
Pierce Christopher
29 Sep 2020
EVP and Chief of Business Oper
Buy
3,750
$19.00
$71.25K
Morosini Deborah
29 Sep 2020
EVP, Chief of Clinical Affairs
Buy
444
$19.00
$8.44K
Dier Mardi
29 Sep 2020
Director
Buy
10,000
$19.00
$190.00K
Combs Andrew
29 Sep 2020
EVP, Head of Chemistry
Buy
1,000
$19.00
$19.00K
BAKER BROS. ADVISORS LP
29 Sep 2020
Director
Buy indirect
1,474,319
$19.00
$28.01M
BAKER BROS. ADVISORS LP
29 Sep 2020
Director
Buy indirect
104,628
$19.00
$1.99M
ORBIMED ADVISORS LLC
25 Sep 2020
Director
Buy indirect
710,500
$19.00
$13.50M
ORBIMED ADVISORS LLC
25 Sep 2020
Director
Buy indirect
526,300
$19.00
$10.00M
Bonita David P
25 Sep 2020
Director
Buy indirect
710,500
$19.00
$13.50M
Bonita David P
25 Sep 2020
Director
Buy indirect
526,300
$19.00
$10.00M

What was left out

Form 4 filings counted 161
Amendments (4/A) skipped 1
Filings about a different issuer 0
Unreadable filings 0
Joint filings 17
Sales on a Rule 10b5-1 plan 0
Sales straight out of an exercise 66
Sales at will 1
Transactions with no price 0
Shares from compensation/vesting 27,573,990
History held since 28 Sep 2020