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Spyre Therapeutics, Inc.

SYRE Scheduled selling only
CIK 0001636282 #969 in the set updated 17 Sep 2026
Bought (12 mo)
$0.00
out of their own pocket, the only kind of buying there is
Sold (12 mo)
$436.71M
$19.58M on a plan · $417.13M straight out of an exercise
Sold at will
$0.00
0 of 79 sales
Net
−$436.71M
$0.00 against sales at will

By person

7 insiders · 79 transactions
74.2×

Cameron Turtle holds 74.2 times base salary in stock. $49.37M of shares against $665.00K in salary for 2025.

Salary from the company's own proxy. The shares are what Cameron Turtle last reported holding, valued at $89.35, the price Common Stock was last bought or sold at on the open market here, on 2 Sep 2026.

Insider
Role
Bought
Sold
Net
Holding
Of company
Worth
Change
Fairmount Funds Management LLC entity
Director
—
$399.66M (1) scheduled
−$399.66M
0
0.0000%
$0.00
−100.0%
Turtle Cameron
Chief Executive Officer
—
$9.99M (34) scheduled
−$9.99M
552,540
0.6266%
$49.37M
−26.1%
HENDERSON MICHAEL THOMAS
Director
—
$7.95M (5) scheduled
−$7.95M
68,606
0.0778%
$6.13M
—
Sloan Sheldon
Chief Medical Officer
—
$7.35M (11) scheduled
−$7.35M
0
0.0000%
$0.00
—
Burrows Scott L
Chief Financial Officer
—
$6.86M (20) scheduled
−$6.86M
79,762
0.0905%
$7.13M
−31.5%
King-Jones Heidy
See Remarks
—
$2.48M (5) scheduled
−$2.48M
2,845
0.0032%
$254.20K
0.0%
Albers Jeffrey W.
Director
—
$2.40M (3) scheduled
−$2.40M
9,360
0.0106%
$836.32K
−72.8%

Individual transactions

79
Insider
Date
Role
Action
Shares
Price
Amount
Burrows Scott L
2 Sep 2026
Chief Financial Officer
Sold on a plan
18,232
$89.35
$1.63M
King-Jones Heidy
2 Sep 2026
See Remarks
Sold after exercise
400
$90.00
$36.00K
Turtle Cameron
1 Sep 2026
Chief Executive Officer
Sold on a plan
400
$89.07
$35.63K
Turtle Cameron
1 Sep 2026
Chief Executive Officer
Sold on a plan
3,700
$88.06
$325.82K
Turtle Cameron
1 Sep 2026
Chief Executive Officer
Sold on a plan
8,400
$87.15
$732.06K
Turtle Cameron
1 Sep 2026
Chief Executive Officer
Sold on a plan
2,500
$86.36
$215.90K
Burrows Scott L
1 Sep 2026
Chief Financial Officer
Sold after exercise
200
$89.04
$17.81K
Burrows Scott L
1 Sep 2026
Chief Financial Officer
Sold after exercise
2,016
$88.03
$177.47K
Burrows Scott L
1 Sep 2026
Chief Financial Officer
Sold after exercise
4,384
$87.11
$381.89K
Burrows Scott L
1 Sep 2026
Chief Financial Officer
Sold after exercise
900
$86.25
$77.63K
King-Jones Heidy
1 Sep 2026
See Remarks
Sold after exercise
400
$89.38
$35.75K
King-Jones Heidy
1 Sep 2026
See Remarks
Sold after exercise
6,206
$88.17
$547.18K
King-Jones Heidy
1 Sep 2026
See Remarks
Sold after exercise
16,548
$87.20
$1.44M
King-Jones Heidy
1 Sep 2026
See Remarks
Sold after exercise
4,845
$86.40
$418.61K
Albers Jeffrey W.
7 Aug 2026
Director
Sold after exercise indirect
10,000
$104.68
$1.05M
Albers Jeffrey W.
7 Aug 2026
Director
Sold after exercise indirect
8,000
$104.38
$835.04K
Albers Jeffrey W.
7 Aug 2026
Director
Sold after exercise
5,000
$104.47
$522.35K
Turtle Cameron
3 Aug 2026
Chief Executive Officer
Sold on a plan
16
$97.46
$1.56K
Turtle Cameron
3 Aug 2026
Chief Executive Officer
Sold on a plan
1,392
$96.82
$134.77K
Turtle Cameron
3 Aug 2026
Chief Executive Officer
Sold on a plan
5,635
$95.93
$540.57K
Turtle Cameron
3 Aug 2026
Chief Executive Officer
Sold on a plan
7,157
$95.10
$680.63K
Turtle Cameron
3 Aug 2026
Chief Executive Officer
Sold on a plan
800
$93.97
$75.18K
Burrows Scott L
3 Aug 2026
Chief Financial Officer
Sold after exercise
100
$97.10
$9.71K
Burrows Scott L
3 Aug 2026
Chief Financial Officer
Sold after exercise
2,300
$96.30
$221.49K
Burrows Scott L
3 Aug 2026
Chief Financial Officer
Sold after exercise
5,100
$95.21
$485.57K
Turtle Cameron
1 Jul 2026
Chief Executive Officer
Sold on a plan
590
$88.91
$52.46K
Turtle Cameron
1 Jul 2026
Chief Executive Officer
Sold on a plan
4,234
$88.12
$373.10K
Turtle Cameron
1 Jul 2026
Chief Executive Officer
Sold on a plan
10,176
$87.44
$889.79K
Sloan Sheldon
1 Jul 2026
Chief Medical Officer
Sold after exercise
1,834
$88.34
$162.02K
Sloan Sheldon
1 Jul 2026
Chief Medical Officer
Sold after exercise
6,500
$87.52
$568.88K
Burrows Scott L
1 Jul 2026
Chief Financial Officer
Sold after exercise
1,725
$88.37
$152.44K
Burrows Scott L
1 Jul 2026
Chief Financial Officer
Sold after exercise
5,775
$87.55
$505.60K
Burrows Scott L
25 Jun 2026
Chief Financial Officer
Sold after exercise
10,000
$87.14
$871.40K
Burrows Scott L
25 Jun 2026
Chief Financial Officer
Sold after exercise
5,000
$87.12
$435.60K
Fairmount Funds Management LLC
23 Jun 2026
Director
Sold after exercise indirect
4,684,781
$85.31
$399.66M
HENDERSON MICHAEL THOMAS
22 Jun 2026
Director
Sold on a plan
20,000
$100.00
$2.00M
Sloan Sheldon
3 Jun 2026
Chief Medical Officer
Sold after exercise
8,333
$75.00
$624.98K
Burrows Scott L
1 Jun 2026
Chief Financial Officer
Sold after exercise
3,100
$72.06
$223.39K
Burrows Scott L
1 Jun 2026
Chief Financial Officer
Sold after exercise
2,599
$70.77
$183.93K
Burrows Scott L
1 Jun 2026
Chief Financial Officer
Sold after exercise
1,801
$69.75
$125.62K
Turtle Cameron
1 Jun 2026
Chief Executive Officer
Sold on a plan
3,294
$71.38
$235.13K
Turtle Cameron
1 Jun 2026
Chief Executive Officer
Sold on a plan
8,149
$70.50
$574.50K
Turtle Cameron
1 Jun 2026
Chief Executive Officer
Sold on a plan
3,557
$69.40
$246.86K
HENDERSON MICHAEL THOMAS
8 May 2026
Director
Sold on a plan
19,269
$75.35
$1.45M
HENDERSON MICHAEL THOMAS
8 May 2026
Director
Sold on a plan
24,814
$74.76
$1.86M
HENDERSON MICHAEL THOMAS
8 May 2026
Director
Sold on a plan
33,513
$73.72
$2.47M
HENDERSON MICHAEL THOMAS
8 May 2026
Director
Sold on a plan
2,404
$72.57
$174.46K
Turtle Cameron
1 May 2026
Chief Executive Officer
Sold on a plan
300
$74.96
$22.49K
Turtle Cameron
1 May 2026
Chief Executive Officer
Sold on a plan
1,700
$74.23
$126.19K
Turtle Cameron
1 May 2026
Chief Executive Officer
Sold on a plan
3,100
$73.14
$226.73K
Turtle Cameron
1 May 2026
Chief Executive Officer
Sold on a plan
1,000
$71.76
$71.76K
Turtle Cameron
1 May 2026
Chief Executive Officer
Sold on a plan
3,600
$70.77
$254.77K
Turtle Cameron
1 May 2026
Chief Executive Officer
Sold on a plan
5,300
$69.54
$368.56K
Sloan Sheldon
1 May 2026
Chief Medical Officer
Sold after exercise
400
$75.37
$30.15K
Sloan Sheldon
1 May 2026
Chief Medical Officer
Sold after exercise
5,059
$74.60
$377.40K
Sloan Sheldon
1 May 2026
Chief Medical Officer
Sold after exercise
10,358
$73.74
$763.80K
Sloan Sheldon
1 May 2026
Chief Medical Officer
Sold after exercise
12,777
$72.94
$931.95K
Sloan Sheldon
1 May 2026
Chief Medical Officer
Sold after exercise
8,777
$71.56
$628.08K
Sloan Sheldon
1 May 2026
Chief Medical Officer
Sold after exercise
19,656
$70.61
$1.39M
Sloan Sheldon
1 May 2026
Chief Medical Officer
Sold after exercise
21,306
$69.53
$1.48M
Burrows Scott L
1 May 2026
Chief Financial Officer
Sold after exercise
12,500
$71.37
$892.13K
Burrows Scott L
1 Apr 2026
Chief Financial Officer
Sold after exercise
1,300
$49.98
$64.97K
Burrows Scott L
1 Apr 2026
Chief Financial Officer
Sold after exercise
6,200
$49.21
$305.10K
Sloan Sheldon
1 Apr 2026
Chief Medical Officer
Sold after exercise
7,958
$50.00
$397.90K
Turtle Cameron
1 Apr 2026
Chief Executive Officer
Sold on a plan
2,656
$49.92
$132.59K
Turtle Cameron
1 Apr 2026
Chief Executive Officer
Sold on a plan
12,344
$49.20
$607.32K
Burrows Scott L
3 Mar 2026
Chief Financial Officer
Sold after exercise
200
$41.66
$8.33K
Burrows Scott L
3 Mar 2026
Chief Financial Officer
Sold after exercise
2,300
$40.56
$93.29K
Turtle Cameron
2 Mar 2026
Chief Executive Officer
Sold on a plan
9,100
$42.49
$386.66K
Turtle Cameron
2 Mar 2026
Chief Executive Officer
Sold on a plan
5,900
$41.73
$246.21K
Turtle Cameron
2 Feb 2026
Chief Executive Officer
Sold on a plan
14,043
$32.87
$461.59K
Turtle Cameron
2 Feb 2026
Chief Executive Officer
Sold on a plan
957
$31.82
$30.45K
Turtle Cameron
2 Jan 2026
Chief Executive Officer
Sold on a plan
100
$32.39
$3.24K
Turtle Cameron
2 Jan 2026
Chief Executive Officer
Sold on a plan
2,191
$31.79
$69.65K
Turtle Cameron
2 Jan 2026
Chief Executive Officer
Sold on a plan
12,709
$30.47
$387.24K
Turtle Cameron
1 Dec 2025
Chief Executive Officer
Sold on a plan
4,005
$29.83
$119.47K
Turtle Cameron
1 Dec 2025
Chief Executive Officer
Sold on a plan
10,995
$28.73
$315.89K
Turtle Cameron
3 Nov 2025
Chief Executive Officer
Sold on a plan
16,845
$23.66
$398.55K
Turtle Cameron
3 Nov 2025
Chief Executive Officer
Sold on a plan
28,155
$23.13
$651.23K

What was left out

Form 4 filings counted 39
Amendments (4/A) skipped 0
Filings about a different issuer 0
Unreadable filings 0
Joint filings 2
Sales on a Rule 10b5-1 plan 40
Sales straight out of an exercise 39
Sales at will 0
Transactions with no price 0
Shares from compensation/vesting 933,764
History held since 16 Feb 2017