InsiderClue
Stocks · Health care · Pharmaceutical Preparations

Karyopharm Therapeutics Inc.

KPTI Clue Score22
United States Fiscal year ends December CIK 0001503802
$0.61 +0.83% Close, 9 Oct 2026
Alert on the numbers Alert on insider trades
Price $0.61 −89.76% Close, 9 Oct 2026

Closing prices at the end of each trading day, from 12 Oct 2016. Not a live quote. Adjusted for share splits, so the line has no step at a split; dividends are not added back.

Revenue and profit

What the business sells, and what is left of it. Point at a year for the detail.
RevenueOperating incomeNet income
Fiscal year 2016Revenue0.2Operating income−110.7Net income−109.6Fiscal year 2017Revenue1.6 +942.2%Operating income−130.5Net income−129.0Fiscal year 2018Revenue30.3 +1,790.1%Operating income−179.9Net income−178.4Fiscal year 2019Revenue40.9 +34.8%Operating income−189.3Net income−199.6Fiscal year 2020Revenue108.1 +164.3%Operating income−171.9Net income−196.3EPS, diluted−2.72Fiscal year 2021Revenue209.8 +94.1%Operating income−98.3Net income−124.1EPS, diluted−1.65Fiscal year 2022Revenue157.1 −25.1%Operating income−142.2Net income−165.3EPS, diluted−2.02Fiscal year 2023Revenue146.0 −7.0%Operating income−129.5Net income−143.1EPS, diluted−18.79Fiscal year 2024Revenue145.2 −0.5%Operating income−119.4Net income−76.4EPS, diluted−14.00Fiscal year 2025Revenue146.1 +0.6%Operating income−90.7Net income−196.0EPS, diluted−17.93
FY2016FY2017FY2018FY2019FY2020FY2021FY2022FY2023FY2024FY2025
Revenue 0.2 1.6 30.3 40.9 108.1 209.8 157.1 146.0 145.2 146.1
Growth +942.2% +1,790.1% +34.8% +164.3% +94.1% −25.1% −7.0% −0.5% +0.6%
Operating income −110.7 −130.5 −179.9 −189.3 −171.9 −98.3 −142.2 −129.5 −119.4 −90.7
Net income −109.6 −129.0 −178.4 −199.6 −196.3 −124.1 −165.3 −143.1 −76.4 −196.0
Growth
EPS, diluted n/a n/a n/a n/a −2.72 −1.65 −2.02 −18.79 −14.00 −17.93

Margins

How much of each dollar of revenue it keeps. Point at a year for the detail.
Operating marginNet margin
Fiscal year 2016Operating margin−71,903.9%Net margin−71,153.9%Free cash flow margin−54,844.8%Fiscal year 2017Operating margin−8,133.2%Net margin−8,036.4%Free cash flow margin−4,596.8%Fiscal year 2018Operating margin−593.0%Net margin−588.1%Free cash flow margin−532.3%Fiscal year 2019Operating margin−462.9%Net margin−488.1%Free cash flow margin−467.1%Fiscal year 2020Operating margin−159.0%Net margin−181.6%Free cash flow margin−148.4%Fiscal year 2021Operating margin−46.8%Net margin−59.1%Free cash flow margin−51.2%Fiscal year 2022Operating margin−90.5%Net margin−105.2%Free cash flow margin−95.3%Fiscal year 2023Operating margin−88.7%Net margin−98.0%Free cash flow margin−63.5%Fiscal year 2024Operating margin−82.2%Net margin−52.6%Free cash flow margin−87.9%Fiscal year 2025Operating margin−62.1%Net margin−134.2%Free cash flow margin−51.6%
FY2016FY2017FY2018FY2019FY2020FY2021FY2022FY2023FY2024FY2025
Operating margin −71,903.9% −8,133.2% −593.0% −462.9% −159.0% −46.8% −90.5% −88.7% −82.2% −62.1%
Net margin −71,153.9% −8,036.4% −588.1% −488.1% −181.6% −59.1% −105.2% −98.0% −52.6% −134.2%
Free cash flow margin −54,844.8% −4,596.8% −532.3% −467.1% −148.4% −51.2% −95.3% −63.5% −87.9% −51.6%

Cash flow

The cash the business makes, what it reinvests, and what it hands back. Point at a year for the detail.
Operating cash flowCapital expenditureFree cash flow
Fiscal year 2016Operating cash flow−84.4Capital expenditure−0.1Free cash flow−84.5Fiscal year 2017Operating cash flow−73.7Capital expenditure−0.1Free cash flow−73.8Fiscal year 2018Operating cash flow−159.1Capital expenditure−2.4Free cash flow−161.5Fiscal year 2019Operating cash flow−190.8Capital expenditure−0.2Free cash flow−191.0Fiscal year 2020Operating cash flow−160.2Capital expenditure−0.1Free cash flow−160.4Fiscal year 2021Operating cash flow−107.1Capital expenditure−0.2Free cash flow−107.3Fiscal year 2022Operating cash flow−149.6Capital expenditure−0.1Free cash flow−149.7Fiscal year 2023Operating cash flow−92.7Capital expenditure0.0Free cash flow−92.7Fiscal year 2024Operating cash flow−127.5Capital expenditure−0.1Free cash flow−127.6Fiscal year 2025Operating cash flow−75.4Capital expenditure0.0Free cash flow−75.4
FY2016FY2017FY2018FY2019FY2020FY2021FY2022FY2023FY2024FY2025
Operating cash flow −84.4 −73.7 −159.1 −190.8 −160.2 −107.1 −149.6 −92.7 −127.5 −75.4
Capital expenditure −0.1 −0.1 −2.4 −0.2 −0.1 −0.2 −0.1 0.0 −0.1 0.0
Free cash flow −84.5 −73.8 −161.5 −191.0 −160.4 −107.3 −149.7 −92.7 −127.6 −75.4
Growth

Balance sheet

What it holds against what it owes, at each year end. Point at a year for the detail.
CashTotal debt
Fiscal year 2016Cash49.7Shareholders’ equity162.2Fiscal year 2017Cash69.0Shareholders’ equity129.5Fiscal year 2018Cash118.0Shareholders’ equity183.2Fiscal year 2019Cash128.9Shareholders’ equity49.8Fiscal year 2020Cash85.9Shareholders’ equity50.5Fiscal year 2021Cash190.5Total debt169.3Net cash (debt)21.2Shareholders’ equity−79.7Fiscal year 2022Cash135.2Shareholders’ equity−16.7Fiscal year 2023Cash52.2Shareholders’ equity−136.2Fiscal year 2024Cash62.5Shareholders’ equity−186.0Fiscal year 2025Cash60.5Shareholders’ equity−292.9
FY2016FY2017FY2018FY2019FY2020FY2021FY2022FY2023FY2024FY2025
Cash 49.7 69.0 118.0 128.9 85.9 190.5 135.2 52.2 62.5 60.5
Total debt n/a n/a n/a n/a n/a 169.3 n/a n/a n/a n/a
Net cash (debt) n/a n/a n/a n/a n/a 21.2 n/a n/a n/a n/a
Shareholders’ equity 162.2 129.5 183.2 49.8 50.5 −79.7 −16.7 −136.2 −186.0 −292.9

In millions of USD, except per-share figures and ratios. Fiscal years, as last filed with the SEC.

Financial statements FY2025 · 10-K

Ratios

Percentages worked out from the filed figures; debt to equity in times. Fiscal years ending December, each column as last filed with the SEC.
Click a line to chart it
Fiscal year FY2016 31 Dec 2016 FY2017 31 Dec 2017 FY2018 31 Dec 2018 FY2019 31 Dec 2019 FY2020 31 Dec 2020 FY2021 31 Dec 2021 FY2022 31 Dec 2022 FY2023 31 Dec 2023 FY2024 31 Dec 2024 FY2025 31 Dec 2025
Margins
−71,903.9% −8,133.2% −593.0% −462.9% −159.0% −46.8% −90.5% −88.7% −82.2% −62.1%
−71,063.6% −8,032.5% −588.0% −488.0% −181.3% −59.0% −105.0% −97.8% −52.6% −134.2%
−71,153.9% −8,036.4% −588.1% −488.1% −181.6% −59.1% −105.2% −98.0% −52.6% −134.2%
−54,844.8% −4,596.8% −532.3% −467.1% −148.4% −51.2% −95.3% −63.5% −87.9% −51.6%
Spending
56,453.2% 6,683.7% 531.9% 299.2% 139.5% 76.7% 94.6% 95.0% 98.6% 86.0%
15,550.6% 1,549.5% 161.0% 257.8% 117.0% 68.6% 92.6% 90.3% 79.5% 72.0%
45.5% 3.9% 7.8% 0.5% 0.1% 0.1% 0.1% 0.0% 0.1% 0.0%
Returns
−67.5% −99.6% −97.4% −401.0% −388.3% n/a n/a n/a n/a n/a
−60.7% −71.5% −52.3% −67.7% −62.7% −40.6% −46.1% −59.5% −46.5% −180.8%
Balance and payout
10.1% 28.2% 46.3% 83.1% 83.9% 126.1% 104.7% 156.6% 213.1% 370.2%