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Stocks · Health care · Pharmaceutical Preparations

Spero Therapeutics, Inc.

SPRO Clue Score55
United States Fiscal year ends December CIK 0001701108
$1.18 -1.67% Close, 12 Oct 2026
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Price $1.18 −93.33% Close, 12 Oct 2026

Closing prices at the end of each trading day, from 2 Nov 2017. Not a live quote. Adjusted for share splits, so the line has no step at a split; dividends are not added back. P/E and P/FCF are the market value over the last full fiscal year's net income or free cash flow, as public on each day, so they step once a year when the annual report comes out. A hatched band marks a stretch with none: a year of net loss, or of cash burnt.

Revenue and profit

What the business sells, and what is left of it. Point at a year for the detail.
RevenueOperating incomeNet income
Fiscal year 2016Revenue0.3Operating income−33.2Net income−25.5Fiscal year 2017Revenue2.0 +490.7%Operating income−41.7Net income−38.7Fiscal year 2018Revenue4.0 +100.4%Operating income−42.8Net income−41.7Fiscal year 2019Revenue4.7 +19.6%Operating income−63.2Net income−60.9Fiscal year 2020Revenue0.3 −94.6%Operating income−79.1Net income−78.3Fiscal year 2021Revenue3.1 +1,089.9%Operating income−88.0Net income−89.8EPS, diluted−2.91Fiscal year 2022Revenue2.5 −18.5%Operating income−42.2Net income−46.4EPS, diluted−1.23Fiscal year 2023Revenue0.9 −62.7%Operating income21.5Net income22.8EPS, diluted0.43Fiscal year 2024Revenue0.4 −60.2%Operating income−73.4Net income−68.6 −400.6%EPS, diluted−1.27 −395.3%Fiscal year 2025Revenue12.6 +3,292.5%Operating income6.3Net income8.6EPS, diluted0.15
FY2016FY2017FY2018FY2019FY2020FY2021FY2022FY2023FY2024FY2025
Revenue 0.3 2.0 4.0 4.7 0.3 3.1 2.5 0.9 0.4 12.6
Growth +490.7% +100.4% +19.6% −94.6% +1,089.9% −18.5% −62.7% −60.2% +3,292.5%
Operating income −33.2 −41.7 −42.8 −63.2 −79.1 −88.0 −42.2 21.5 −73.4 6.3
Net income −25.5 −38.7 −41.7 −60.9 −78.3 −89.8 −46.4 22.8 −68.6 8.6
Growth −400.6%
EPS, diluted n/a n/a n/a n/a n/a −2.91 −1.23 0.43 −1.27 0.15
Growth −395.3%

Margins

How much of each dollar of revenue it keeps. Point at a year for the detail.
Operating marginNet margin
Fiscal year 2016Operating margin−9,916.7%Net margin−7,609.3%Free cash flow margin−8,892.2%Fiscal year 2017Operating margin−2,108.6%Net margin−1,957.7%Free cash flow margin−1,977.7%Fiscal year 2018Operating margin−1,079.3%Net margin−1,051.4%Free cash flow margin−1,060.5%Fiscal year 2019Operating margin−1,333.1%Net margin−1,284.3%Free cash flow margin−1,061.5%Fiscal year 2020Operating margin−30,664.0%Net margin−30,348.8%Free cash flow margin−33,344.6%Fiscal year 2021Operating margin−2,865.5%Net margin−2,925.1%Fiscal year 2022Operating margin−1,685.9%Net margin−1,854.4%Fiscal year 2023Operating margin2,302.4%Net margin2,444.4%Fiscal year 2024Operating margin−19,773.9%Net margin−18,481.4%Fiscal year 2025Operating margin50.2%Net margin68.1%
FY2016FY2017FY2018FY2019FY2020FY2021FY2022FY2023FY2024FY2025
Operating margin −9,916.7% −2,108.6% −1,079.3% −1,333.1% −30,664.0% −2,865.5% −1,685.9% 2,302.4% −19,773.9% 50.2%
Net margin −7,609.3% −1,957.7% −1,051.4% −1,284.3% −30,348.8% −2,925.1% −1,854.4% 2,444.4% −18,481.4% 68.1%
Free cash flow margin −8,892.2% −1,977.7% −1,060.5% −1,061.5% −33,344.6% n/a n/a n/a n/a n/a

Cash flow

The cash the business makes, what it reinvests, and what it hands back. Point at a year for the detail.
Operating cash flowCapital expenditureFree cash flow
Fiscal year 2016Operating cash flow−29.0Capital expenditure−0.8Free cash flow−29.8Fiscal year 2017Operating cash flow−39.1Capital expenditure−0.0Free cash flow−39.1Fiscal year 2018Operating cash flow−39.6Capital expenditure−2.4Free cash flow−42.1Fiscal year 2019Operating cash flow−50.0Capital expenditure−0.3Free cash flow−50.3Fiscal year 2020Operating cash flow−85.9Capital expenditure−0.2Free cash flow−86.0Fiscal year 2021Operating cash flow−64.3Fiscal year 2022Operating cash flow−7.7Fiscal year 2023Operating cash flow−33.0Fiscal year 2024Operating cash flow−23.4Fiscal year 2025Operating cash flow−12.6
FY2016FY2017FY2018FY2019FY2020FY2021FY2022FY2023FY2024FY2025
Operating cash flow −29.0 −39.1 −39.6 −50.0 −85.9 −64.3 −7.7 −33.0 −23.4 −12.6
Capital expenditure −0.8 −0.0 −2.4 −0.3 −0.2 n/a n/a n/a n/a n/a
Free cash flow −29.8 −39.1 −42.1 −50.3 −86.0 n/a n/a n/a n/a n/a
Growth

Balance sheet

What it holds against what it owes, at each year end. Point at a year for the detail.
Cash
Fiscal year 2016Cash10.3Shareholders’ equity−45.4Fiscal year 2017Cash87.3Shareholders’ equity84.6Fiscal year 2018Cash34.1Shareholders’ equity115.5Fiscal year 2019Cash29.7Shareholders’ equity74.6Fiscal year 2020Cash85.2Shareholders’ equity132.0Fiscal year 2021Cash112.6Shareholders’ equity88.3Fiscal year 2022Cash109.1Shareholders’ equity75.9Fiscal year 2023Cash76.3Shareholders’ equity106.9Fiscal year 2024Cash52.9Shareholders’ equity46.1Fiscal year 2025Cash40.3Shareholders’ equity59.0
FY2016FY2017FY2018FY2019FY2020FY2021FY2022FY2023FY2024FY2025
Cash 10.3 87.3 34.1 29.7 85.2 112.6 109.1 76.3 52.9 40.3
Shareholders’ equity −45.4 84.6 115.5 74.6 132.0 88.3 75.9 106.9 46.1 59.0

In millions of USD, except per-share figures and ratios. Fiscal years, as last filed with the SEC.

Financial statements FY2025 · 10-K

Income statement

In millions of USD, except per-share figures; shares in millions. Fiscal years ending December, each column as last filed with the SEC.
Click a line to chart it
Fiscal year FY2016 31 Dec 2016 FY2017 31 Dec 2017 FY2018 31 Dec 2018 FY2019 31 Dec 2019 FY2020 31 Dec 2020 FY2021 31 Dec 2021 FY2022 31 Dec 2022 FY2023 31 Dec 2023 FY2024 31 Dec 2024 FY2025 31 Dec 2025
Revenue and profit
0.3 2.0 4.0 4.7 0.3 3.1 2.5 0.9 0.4 12.6
Growth +490.7% +100.4% +19.6% −94.6% +1,089.9% −18.5% −62.7% −60.2% +3,292.5%
26.3 32.9 33.9 65.8 67.0 64.5 47.6 51.4 96.8 38.5
7.2 10.8 12.9 15.6 21.4 41.7 36.5 25.6 23.7 21.2
−33.2 −41.7 −42.8 −63.2 −79.1 −88.0 −42.2 21.5 −73.4 6.3
Growth −441.5%
−32.6 −39.9 −41.7 −60.9 −78.3 −89.8 −46.4 25.4 −68.6 8.8
0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.6 0.0 0.3
−25.5 −38.7 −41.7 −60.9 −78.3 −89.8 −46.4 22.8 −68.6 8.6
Growth −400.6%
Per share
n/a n/a n/a n/a n/a −2.91 −1.23 0.43 −1.27 0.15
n/a n/a n/a n/a n/a −2.91 −1.23 0.43 −1.27 0.15
Growth −395.3%
n/a n/a n/a n/a n/a 30.9 37.6 52.7 54.0 56.0
n/a n/a n/a n/a n/a 30.9 37.6 53.0 54.0 59.0
Growth +21.7% +41.0% +2.0% +9.3%

Five years in brief

Worked out from the figures above, not from a press release
  • Revenue grew 117.6% a year over five years.
  • Operating margin is up 30,714.1 points on five years ago, at 50.2%.
  • A net loss in 8 of 10 years on file.