Insider
Date
Role
Action
Shares
Price
Amount
George M Milne Jr
5 Oct 2026
Director
Sold on a plan
30,000
$27.70
$830.90K
Joshua B Cohen
10 Sep 2026
Co-Chief Executive Officer
Sell
919
$33.15
$30.46K
Joshua B Cohen
10 Sep 2026
Co-Chief Executive Officer
Sell
29,545
$32.16
$950.04K
Justin B. Klee
10 Sep 2026
Co-Chief Executive Officer
Sell
1,439
$33.16
$47.71K
Justin B. Klee
10 Sep 2026
Co-Chief Executive Officer
Sell
29,025
$32.13
$932.55K
Gina Mazzariello
10 Sep 2026
Chief Legal Officer
Sell
11
$33.34
$366.74
Gina Mazzariello
10 Sep 2026
Chief Legal Officer
Sell
9,525
$32.46
$309.14K
James M Frates
10 Sep 2026
Chief Financial Officer
Sell
1,042
$33.23
$34.63K
James M Frates
10 Sep 2026
Chief Financial Officer
Sell
9,768
$32.27
$315.19K
Camille L Bedrosian
10 Sep 2026
Chief Medical Officer
Sell
2,081
$33.09
$68.86K
Camille L Bedrosian
10 Sep 2026
Chief Medical Officer
Sell
7,947
$32.21
$256.00K
Karen Firestone
31 Aug 2026
Director
Exercised, kept
25,000
$5.05
$126.25K
Karen Firestone
31 Aug 2026
Director
Exercised, kept
25,000
$1.76
$44.00K
Gina Mazzariello
10 Jul 2026
Chief Legal Officer
Sold on a plan
15,000
$17.61
$264.12K
Gina Mazzariello
9 Jul 2026
Chief Legal Officer
Sold on a plan
15,000
$18.32
$274.75K
Karen Firestone
21 May 2026
Director
Buy
3,800
$13.51
$51.34K
Gina Mazzariello
2 Mar 2026
Chief Legal Officer
Sell
6,844
$14.52
$99.38K
James M Frates
2 Mar 2026
Chief Financial Officer
Sell
7,909
$14.52
$114.85K
Camille L Bedrosian
2 Mar 2026
Chief Medical Officer
Sell
6,461
$14.58
$94.21K
Joshua B Cohen
2 Mar 2026
Co-Chief Executive Officer
Sell
29,282
$14.48
$424.12K
Justin B. Klee
2 Mar 2026
Co-Chief Executive Officer
Sell
29,282
$14.47
$423.76K
Gina Mazzariello
23 Feb 2026
Chief Legal Officer
Sell
3,419
$14.14
$48.35K
Justin B. Klee
2 Feb 2026
Co-Chief Executive Officer
Sell
15,500
$14.69
$227.62K
Gina Mazzariello
2 Feb 2026
Chief Legal Officer
Sell
3,448
$14.65
$50.52K
Joshua B Cohen
2 Feb 2026
Co-Chief Executive Officer
Sell
15,500
$14.68
$227.59K
James M Frates
2 Feb 2026
Chief Financial Officer
Sell
3,557
$14.65
$52.10K
Justin B. Klee
16 Jan 2026
Co-Chief Executive Officer
Sold after exercise
1,995
$13.89
$27.70K
Joshua B Cohen
16 Jan 2026
Co-Chief Executive Officer
Sold after exercise
1,974
$13.83
$27.30K
Justin B. Klee
15 Jan 2026
Co-Chief Executive Officer
Sold after exercise
136,193
$13.58
$1.85M
Joshua B Cohen
15 Jan 2026
Co-Chief Executive Officer
Sold after exercise
136,193
$13.59
$1.85M
Justin B. Klee
6 Jan 2026
Co-Chief Executive Officer
Sell
7,715
$11.09
$85.59K
Joshua B Cohen
6 Jan 2026
Co-Chief Executive Officer
Sell
7,715
$11.09
$85.60K
James M Frates
6 Jan 2026
Chief Financial Officer
Sell
3,326
$11.11
$36.95K
Karen Firestone
23 Dec 2025
Director
Buy
8,100
$12.45
$100.85K
Camille L Bedrosian
1 Dec 2025
Chief Medical Officer
Sell
6,580
$14.35
$94.42K
Camille L Bedrosian
30 Sep 2025
Chief Medical Officer
Sell
12,039
$14.58
$175.52K
Joshua B Cohen
30 Sep 2025
Co-Chief Executive Officer
Sell
200
$15.00
$3.00K
Joshua B Cohen
30 Sep 2025
Co-Chief Executive Officer
Sell
29,733
$14.34
$426.47K
James M Frates
30 Sep 2025
Chief Financial Officer
Sell
10,558
$14.65
$154.65K
Gina Mazzariello
30 Sep 2025
Chief Legal Officer
Sell
8,828
$14.58
$128.67K
Justin B. Klee
30 Sep 2025
Co-Chief Executive Officer
Sell
200
$15.01
$3.00K
Justin B. Klee
30 Sep 2025
Co-Chief Executive Officer
Sell
29,775
$14.37
$427.95K
Gina Mazzariello
13 Aug 2025
Chief Legal Officer
Sold on a plan
15,000
$8.34
$125.05K
Gina Mazzariello
12 Aug 2025
Chief Legal Officer
Sold on a plan
15,000
$8.07
$121.10K
Justin B. Klee
31 Mar 2025
Co-Chief Executive Officer
Sell
21,490
$3.46
$74.45K
Joshua B Cohen
31 Mar 2025
Co-Chief Executive Officer
Sell
21,490
$3.47
$74.48K
Gina Mazzariello
31 Mar 2025
Chief Legal Officer
Sell
9,192
$3.48
$31.95K
Camille L Bedrosian
31 Mar 2025
Chief Medical Officer
Sell
12,425
$3.47
$43.08K
James M Frates
31 Mar 2025
Chief Financial Officer
Sell
10,896
$3.47
$37.81K
Bernhardt G Zeiher
20 Mar 2025
Director
Buy
10,000
$3.70
$37.01K
Gina Mazzariello
3 Mar 2025
Chief Legal Officer
Sell
1,611
$3.12
$5.02K
Joshua B Cohen
3 Mar 2025
Co-Chief Executive Officer
Sell
4,595
$3.17
$14.55K
Justin B. Klee
3 Mar 2025
Co-Chief Executive Officer
Sell
4,595
$3.15
$14.48K
Gina Mazzariello
24 Feb 2025
Chief Legal Officer
Sell
4,169
$3.15
$13.14K
Justin B. Klee
5 Feb 2025
Co-Chief Executive Officer
Exercised, kept
36,310
$1.57
$57.01K
Justin B. Klee
3 Feb 2025
Co-Chief Executive Officer
Sell
11,855
$3.47
$41.10K
Joshua B Cohen
3 Feb 2025
Co-Chief Executive Officer
Sell
11,851
$3.47
$41.11K
Gina Mazzariello
3 Feb 2025
Chief Legal Officer
Sell
3,678
$3.49
$12.84K
Joshua B Cohen
6 Jan 2025
Co-Chief Executive Officer
Sell
7,471
$4.05
$30.23K
Justin B. Klee
6 Jan 2025
Co-Chief Executive Officer
Sell
7,471
$4.04
$30.20K
Camille L Bedrosian
2 Dec 2024
Chief Medical Officer
Sell
5,421
$5.54
$30.01K
Justin B. Klee
4 Nov 2024
Co-Chief Executive Officer
Exercised, kept
63,690
$1.57
$99.99K
Gina Mazzariello
30 Sep 2024
Chief Legal Officer
Sell
8,709
$3.20
$27.84K
Camille L Bedrosian
30 Sep 2024
Chief Medical Officer
Sell
11,442
$3.20
$36.56K
Joshua B Cohen
30 Sep 2024
Co-Chief Executive Officer
Sell
18,589
$3.20
$59.41K
Justin B. Klee
30 Sep 2024
Co-Chief Executive Officer
Sell
18,589
$3.20
$59.43K
Joshua B Cohen
23 Sep 2024
Co-Chief Executive Officer
Exercised, kept
1,857
$1.57
$2.92K
James M Frates
12 Sep 2024
Chief Financial Officer
Buy
40,000
$2.53
$101.37K
Joshua B Cohen
12 Sep 2024
Co-Chief Executive Officer
Exercised, kept
34,449
$1.57
$54.08K
Karen Firestone
5 Sep 2024
Director
Buy
50,000
$2.13
$106.59K
George M Milne Jr
3 Sep 2024
Director
Buy
100,000
$2.20
$219.80K
Gina Mazzariello
15 May 2024
Chief Legal Officer
Sold on a plan
10,455
$1.88
$19.65K
Daphne Quimi
15 May 2024
Director
Buy
2,250
$1.89
$4.25K
Daphne Quimi
14 May 2024
Director
Buy
2,750
$1.89
$5.18K
Gina Mazzariello
5 Mar 2024
Chief Legal Officer
Sell
1,540
$18.73
$28.84K
James M Frates
5 Mar 2024
Chief Financial Officer
Sell
1,792
$18.73
$33.56K
Justin B. Klee
5 Mar 2024
Co-Chief Executive Officer
Sell
4,135
$18.73
$77.44K
Joshua B Cohen
5 Mar 2024
Co-Chief Executive Officer
Sell
4,135
$18.73
$77.44K
Gina Mazzariello
23 Feb 2024
Chief Legal Officer
Sell
2,838
$18.76
$53.23K
Patrick D Yeramian
9 Jan 2024
Chief Medical Officer
Sell
2,812
$16.33
$45.91K
Joshua B Cohen
9 Jan 2024
Co-Chief Executive Officer
Sell
5,841
$16.33
$95.37K
James M Frates
9 Jan 2024
Chief Financial Officer
Sell
2,716
$16.33
$44.35K
Justin B. Klee
9 Jan 2024
Co-Chief Executive Officer
Sell
5,841
$16.33
$95.37K
Margaret Olinger
27 Dec 2023
Chief Commercial Officer
Exercised, kept
25,000
$0.37
$9.25K
Karen Firestone
15 Dec 2023
Director
Buy
4,000
$14.97
$59.88K
Joshua B Cohen
16 Nov 2023
Co-Chief Executive Officer
Exercised, kept
63,694
$1.57
$100.00K
James M Frates
23 Aug 2023
Chief Financial Officer
Exercised, kept
18,165
$6.88
$124.98K
Gina Mazzariello
15 Aug 2023
Chief Legal Officer
Sold on a plan
6,164
$20.88
$128.69K
Margaret Olinger
12 Jul 2023
Chief Commercial Officer
Exercised, kept
20,000
$0.37
$7.40K
James M Frates
16 May 2023
Chief Financial Officer
Sold after exercise
500
$27.60
$13.80K
James M Frates
16 May 2023
Chief Financial Officer
Sold after exercise
32,000
$26.93
$861.65K
Patrick D Yeramian
15 May 2023
Chief Medical Officer
Sold after exercise
11,965
$29.03
$347.36K
Patrick D Yeramian
17 Apr 2023
Chief Medical Officer
Sold after exercise
300
$30.94
$9.28K
Patrick D Yeramian
17 Apr 2023
Chief Medical Officer
Sold after exercise
49,279
$30.53
$1.50M
Morningside Venture Investments Ltd
29 Mar 2023
10% owner
Sell
29,048
$30.45
$884.51K
Morningside Venture Investments Ltd
28 Mar 2023
10% owner
Sell
100,000
$30.37
$3.04M
Morningside Venture Investments Ltd
27 Mar 2023
10% owner
Sell
28,000
$30.80
$862.40K
Morningside Venture Investments Ltd
27 Mar 2023
10% owner
Sell
32,964
$30.25
$997.16K
Morningside Venture Investments Ltd
21 Mar 2023
10% owner
Sell
28,807
$32.17
$926.72K
Morningside Venture Investments Ltd
21 Mar 2023
10% owner
Sell
34,641
$31.69
$1.10M
Morningside Venture Investments Ltd
16 Mar 2023
10% owner
Sell
9,122
$32.55
$296.92K
James M Frates
16 Mar 2023
Chief Financial Officer
Sell
1,704
$32.46
$55.32K
James M Frates
16 Mar 2023
Chief Financial Officer
Sell
30,796
$31.86
$981.14K
Joshua B Cohen
16 Mar 2023
Co-Chief Executive Officer
Sell
3,924
$32.45
$127.31K
Joshua B Cohen
16 Mar 2023
Co-Chief Executive Officer
Sell
96,076
$31.84
$3.06M
Karen Firestone
16 Mar 2023
Director
Buy
1,000
$31.99
$31.99K
Patrick D Yeramian
16 Mar 2023
Chief Medical Officer
Sell
2,416
$32.43
$78.36K
Patrick D Yeramian
16 Mar 2023
Chief Medical Officer
Sell
52,211
$31.85
$1.66M
George M Milne Jr
16 Mar 2023
Director
Sell
1,916
$32.45
$62.17K
George M Milne Jr
16 Mar 2023
Director
Sell
33,084
$31.86
$1.05M
Justin B. Klee
16 Mar 2023
Co-Chief Executive Officer
Sell
3,445
$32.48
$111.88K
Justin B. Klee
16 Mar 2023
Co-Chief Executive Officer
Sell
96,555
$31.84
$3.07M
Morningside Venture Investments Ltd
15 Mar 2023
10% owner
Sell
41,066
$33.68
$1.38M
Morningside Venture Investments Ltd
15 Mar 2023
10% owner
Sell
108,934
$33.12
$3.61M
Morningside Venture Investments Ltd
14 Mar 2023
10% owner
Sell
70,714
$34.54
$2.44M
Morningside Venture Investments Ltd
2 Mar 2023
10% owner
Sell
50,000
$33.75
$1.69M
Gina Mazzariello
24 Feb 2023
Chief Legal Officer
Sell
3,586
$34.49
$123.67K
Morningside Venture Investments Ltd
23 Feb 2023
10% owner
Sell
1,111
$36.24
$40.26K
Morningside Venture Investments Ltd
23 Feb 2023
10% owner
Sell
48,889
$35.55
$1.74M
Morningside Venture Investments Ltd
22 Feb 2023
10% owner
Sell
10,084
$36.34
$366.45K
Morningside Venture Investments Ltd
22 Feb 2023
10% owner
Sell
39,916
$35.91
$1.43M
Morningside Venture Investments Ltd
22 Feb 2023
10% owner
Sell
2,112
$35.34
$74.64K
Morningside Venture Investments Ltd
22 Feb 2023
10% owner
Sell
47,888
$34.70
$1.66M
Justin B. Klee
6 Jan 2023
Co-Chief Executive Officer
Sell
1,846
$36.79
$67.91K
Justin B. Klee
6 Jan 2023
Co-Chief Executive Officer
Sell
4,122
$36.08
$148.72K
Margaret Olinger
6 Jan 2023
Chief Commercial Officer
Sell
743
$36.79
$27.33K
Margaret Olinger
6 Jan 2023
Chief Commercial Officer
Sell
1,660
$36.08
$59.89K
James M Frates
6 Jan 2023
Chief Financial Officer
Sell
822
$36.79
$30.24K
James M Frates
6 Jan 2023
Chief Financial Officer
Sell
1,836
$36.08
$66.24K
Joshua B Cohen
6 Jan 2023
Co-Chief Executive Officer
Sell
1,846
$36.79
$67.91K
Joshua B Cohen
6 Jan 2023
Co-Chief Executive Officer
Sell
4,122
$36.08
$148.72K
Patrick D Yeramian
6 Jan 2023
Chief Medical Officer
Sell
629
$36.79
$23.14K
Patrick D Yeramian
6 Jan 2023
Chief Medical Officer
Sell
1,405
$36.08
$50.69K
James M Frates
30 Dec 2022
Chief Financial Officer
Exercised, kept
5,000
$6.88
$34.40K
Viking Global Investors LP
9 Sep 2022
10% owner
Sell
indirect
3,142
$31.44
$98.79K
Viking Global Investors LP
9 Sep 2022
10% owner
Sell
indirect
73,886
$30.90
$2.28M
Viking Global Investors LP
9 Sep 2022
10% owner
Sell
indirect
147,502
$29.87
$4.41M
Viking Global Investors LP
9 Sep 2022
10% owner
Sell
indirect
6,654
$31.44
$209.22K
Viking Global Investors LP
9 Sep 2022
10% owner
Sell
indirect
156,463
$30.90
$4.83M
Viking Global Investors LP
9 Sep 2022
10% owner
Sell
indirect
312,353
$29.87
$9.33M
Viking Global Investors LP
8 Sep 2022
10% owner
Sell
indirect
52,466
$32.23
$1.69M
Viking Global Investors LP
8 Sep 2022
10% owner
Sell
indirect
7,554
$30.59
$231.06K
Viking Global Investors LP
8 Sep 2022
10% owner
Sell
indirect
75,096
$29.14
$2.19M
Viking Global Investors LP
8 Sep 2022
10% owner
Sell
indirect
51,298
$28.16
$1.44M
Viking Global Investors LP
8 Sep 2022
10% owner
Sell
indirect
38,116
$27.28
$1.04M
Viking Global Investors LP
8 Sep 2022
10% owner
Sell
indirect
111,102
$32.23
$3.58M
Viking Global Investors LP
8 Sep 2022
10% owner
Sell
indirect
15,996
$30.59
$489.28K
Viking Global Investors LP
8 Sep 2022
10% owner
Sell
indirect
159,026
$29.14
$4.63M
Viking Global Investors LP
8 Sep 2022
10% owner
Sell
indirect
108,631
$28.16
$3.06M
Viking Global Investors LP
8 Sep 2022
10% owner
Sell
indirect
80,715
$27.28
$2.20M
Invest 1 B.V. ALS
6 Jul 2022
10% owner
Sell
2,307
$22.42
$51.72K
Invest 1 B.V. ALS
6 Jul 2022
10% owner
Sell
29,595
$21.32
$630.97K
Invest 1 B.V. ALS
6 Jul 2022
10% owner
Sell
10,395
$20.60
$214.14K
Invest 1 B.V. ALS
6 Jul 2022
10% owner
Sell
18,312
$19.54
$357.82K
Joshua B Cohen
5 May 2022
Co-Chief Executive Officer
Exercised, kept
334,520
$0.37
$123.77K
Justin B. Klee
5 May 2022
Co-Chief Executive Officer
Exercised, kept
334,520
$0.37
$123.77K
Viking Global Investors LP
11 Jan 2022
10% owner
Buy
indirect
2,300,000
$19.00
$43.70M
Morningside Venture Investments Ltd
11 Jan 2022
10% owner
Buy
263,158
$19.00
$5.00M
Margaret Olinger
6 Jan 2022
Chief Commercial Officer
Buy
6,842
$19.00
$130.00K
George M Milne Jr
6 Jan 2022
Director
Buy
26,315
$19.00
$499.99K
Isaac Cheng
6 Jan 2022
Director
Buy
6,578
$19.00
$124.98K
Paul R. Fonteyne
6 Jan 2022
Director
Buy
3,947
$19.00
$74.99K
