Stocks · Health care · Pharmaceutical Preparations

IONIS PHARMACEUTICALS INC

IONS Clue Score34
United States Fiscal year ends December CIK 0000874015
45.28
+4.57%
Close, 9 Oct 2026 · USD

Price, with every insider trade on it

Closing prices, 12 months · point at a dot for who traded, or at the line for the close
45.28 on 9 Oct 2026
87 65 43 Oct 2025 Apr 2026 Oct 2026 13 Oct 2025 $70.59 14 Oct 2025 $71.37 15 Oct 2025 $72.39 16 Oct 2025 $73.07 17 Oct 2025 $73.09 20 Oct 2025 $73.55 21 Oct 2025 $71.64 22 Oct 2025 $71.50 23 Oct 2025 $71.50 24 Oct 2025 $70.86 27 Oct 2025 $72.99 28 Oct 2025 $73.57 29 Oct 2025 $71.88 30 Oct 2025 $74.17 31 Oct 2025 $74.30 3 Nov 2025 $73.65 4 Nov 2025 $72.88 5 Nov 2025 $74.68 6 Nov 2025 $74.10 7 Nov 2025 $73.55 10 Nov 2025 $69.54 11 Nov 2025 $72.45 12 Nov 2025 $72.67 13 Nov 2025 $69.84 14 Nov 2025 $71.55 17 Nov 2025 $73.26 18 Nov 2025 $74.50 19 Nov 2025 $74.00 20 Nov 2025 $73.12 21 Nov 2025 $76.09 24 Nov 2025 $78.52 25 Nov 2025 $80.93 26 Nov 2025 $82.70 28 Nov 2025 $82.73 1 Dec 2025 $81.99 2 Dec 2025 $81.31 3 Dec 2025 $81.84 4 Dec 2025 $81.81 5 Dec 2025 $81.68 8 Dec 2025 $81.51 9 Dec 2025 $78.86 10 Dec 2025 $78.63 11 Dec 2025 $79.14 12 Dec 2025 $80.82 15 Dec 2025 $79.76 16 Dec 2025 $78.37 17 Dec 2025 $77.08 18 Dec 2025 $77.63 19 Dec 2025 $79.57 22 Dec 2025 $81.34 23 Dec 2025 $80.33 24 Dec 2025 $80.65 26 Dec 2025 $79.93 29 Dec 2025 $79.98 30 Dec 2025 $78.97 31 Dec 2025 $79.11 2 Jan 2026 $79.67 5 Jan 2026 $78.53 6 Jan 2026 $81.49 7 Jan 2026 $83.17 8 Jan 2026 $81.54 9 Jan 2026 $80.30 12 Jan 2026 $81.66 13 Jan 2026 $79.48 14 Jan 2026 $78.87 15 Jan 2026 $77.21 16 Jan 2026 $76.33 20 Jan 2026 $77.53 21 Jan 2026 $79.44 22 Jan 2026 $81.79 23 Jan 2026 $80.29 26 Jan 2026 $81.00 27 Jan 2026 $82.14 28 Jan 2026 $81.92 29 Jan 2026 $83.88 30 Jan 2026 $82.67 2 Feb 2026 $83.07 3 Feb 2026 $84.59 4 Feb 2026 $84.99 5 Feb 2026 $83.48 6 Feb 2026 $86.50 9 Feb 2026 $84.79 10 Feb 2026 $84.29 11 Feb 2026 $84.35 12 Feb 2026 $81.78 13 Feb 2026 $80.60 17 Feb 2026 $81.36 18 Feb 2026 $82.22 19 Feb 2026 $83.15 20 Feb 2026 $83.15 23 Feb 2026 $84.60 24 Feb 2026 $85.45 25 Feb 2026 $80.93 26 Feb 2026 $80.60 27 Feb 2026 $81.15 2 Mar 2026 $81.96 3 Mar 2026 $78.66 4 Mar 2026 $79.45 5 Mar 2026 $75.16 6 Mar 2026 $74.04 9 Mar 2026 $75.36 10 Mar 2026 $75.66 11 Mar 2026 $74.79 12 Mar 2026 $72.34 13 Mar 2026 $71.19 16 Mar 2026 $72.34 17 Mar 2026 $72.33 18 Mar 2026 $71.67 19 Mar 2026 $71.32 20 Mar 2026 $70.99 23 Mar 2026 $70.79 24 Mar 2026 $69.68 25 Mar 2026 $72.70 26 Mar 2026 $74.24 27 Mar 2026 $72.15 30 Mar 2026 $72.52 31 Mar 2026 $75.09 1 Apr 2026 $75.13 2 Apr 2026 $74.79 6 Apr 2026 $74.33 7 Apr 2026 $73.89 8 Apr 2026 $74.98 9 Apr 2026 $76.43 10 Apr 2026 $75.17 13 Apr 2026 $74.95 14 Apr 2026 $76.76 15 Apr 2026 $76.82 16 Apr 2026 $75.26 17 Apr 2026 $75.71 20 Apr 2026 $74.87 21 Apr 2026 $74.78 22 Apr 2026 $74.83 23 Apr 2026 $74.09 24 Apr 2026 $73.27 27 Apr 2026 $72.23 28 Apr 2026 $71.78 29 Apr 2026 $74.83 30 Apr 2026 $74.76 1 May 2026 $75.28 4 May 2026 $75.45 5 May 2026 $75.25 6 May 2026 $76.85 7 May 2026 $76.02 8 May 2026 $75.71 11 May 2026 $75.38 12 May 2026 $75.83 13 May 2026 $77.60 14 May 2026 $75.68 15 May 2026 $74.23 18 May 2026 $72.52 19 May 2026 $73.84 20 May 2026 $75.06 21 May 2026 $75.78 22 May 2026 $75.56 26 May 2026 $76.07 27 May 2026 $76.49 28 May 2026 $77.33 29 May 2026 $76.50 1 Jun 2026 $75.38 2 Jun 2026 $72.97 3 Jun 2026 $73.82 4 Jun 2026 $75.13 5 Jun 2026 $74.48 8 Jun 2026 $73.54 9 Jun 2026 $74.58 10 Jun 2026 $73.32 11 Jun 2026 $73.82 12 Jun 2026 $73.28 15 Jun 2026 $73.96 16 Jun 2026 $73.09 17 Jun 2026 $74.31 18 Jun 2026 $74.12 22 Jun 2026 $75.89 23 Jun 2026 $75.99 24 Jun 2026 $76.52 25 Jun 2026 $78.34 26 Jun 2026 $81.18 29 Jun 2026 $80.69 30 Jun 2026 $79.29 1 Jul 2026 $79.19 2 Jul 2026 $81.80 6 Jul 2026 $83.18 7 Jul 2026 $86.33 8 Jul 2026 $84.46 9 Jul 2026 $64.27 10 Jul 2026 $58.25 13 Jul 2026 $56.75 14 Jul 2026 $54.93 15 Jul 2026 $54.73 16 Jul 2026 $54.65 17 Jul 2026 $54.39 20 Jul 2026 $52.95 21 Jul 2026 $53.39 22 Jul 2026 $54.01 23 Jul 2026 $55.87 24 Jul 2026 $56.55 27 Jul 2026 $55.96 28 Jul 2026 $55.30 29 Jul 2026 $54.04 30 Jul 2026 $53.28 31 Jul 2026 $51.77 3 Aug 2026 $54.49 4 Aug 2026 $55.07 5 Aug 2026 $54.19 6 Aug 2026 $54.49 7 Aug 2026 $56.56 10 Aug 2026 $56.94 11 Aug 2026 $55.42 12 Aug 2026 $56.53 13 Aug 2026 $55.87 14 Aug 2026 $57.24 17 Aug 2026 $58.63 18 Aug 2026 $59.62 19 Aug 2026 $60.80 20 Aug 2026 $58.76 21 Aug 2026 $59.74 24 Aug 2026 $62.04 25 Aug 2026 $63.57 26 Aug 2026 $63.36 27 Aug 2026 $62.43 28 Aug 2026 $61.05 31 Aug 2026 $60.36 1 Sep 2026 $59.88 2 Sep 2026 $61.33 3 Sep 2026 $58.13 4 Sep 2026 $58.09 8 Sep 2026 $56.71 9 Sep 2026 $56.02 10 Sep 2026 $55.65 11 Sep 2026 $54.21 14 Sep 2026 $51.44 15 Sep 2026 $47.25 16 Sep 2026 $44.84 17 Sep 2026 $46.75 18 Sep 2026 $44.44 21 Sep 2026 $44.90 22 Sep 2026 $45.75 23 Sep 2026 $43.93 24 Sep 2026 $43.81 25 Sep 2026 $44.50 28 Sep 2026 $45.57 29 Sep 2026 $45.89 30 Sep 2026 $44.65 1 Oct 2026 $44.00 2 Oct 2026 $43.54 5 Oct 2026 $43.50 6 Oct 2026 $44.00 7 Oct 2026 $44.16 8 Oct 2026 $43.30 9 Oct 2026 $45.28 Birchler Brian EVP, Corp and Development Ops Sold on a plan $826.59K 14 Oct 2025 · at $72.03 · 16.8% of stake PARSHALL B LYNNE Director Sold on a plan $358.72K 15 Oct 2025 · at $71.74 · 7.5% of stake Devers Shannon L. EVP, Chief Human Resources Ofc Sold on a plan $437.65K 15 Oct 2025 · at $72.94 · 27.4% of stake Birchler Brian EVP, Corp and Development Ops Sold on a plan $897.40K 15 Oct 2025 · at $72.23 · 17.9% of stake Swayze Eric EVP Research Sold at will $3.90K 16 Oct 2025 · at $73.62 · 17.2% of stake Devers Shannon L. EVP, Chief Human Resources Ofc Sold on a plan $92.98K 16 Oct 2025 · at $73.62 · 6.7% of stake WENDER JOSEPH H Director Sold on a plan $1.23M 30 Oct 2025 · at $73.26 · 18.3% of stake WENDER JOSEPH H Director Sold on a plan $841.78K 31 Oct 2025 · at $75.16 · 14.9% of stake LOSCALZO JOSEPH Director Sold on a plan $1.20M 31 Oct 2025 · at $75.10 · 30.6% of stake Geary Richard S EVP, Chief Development Officer Sold on a plan $6.70M 31 Oct 2025 · at $75.11 · 59.9% of stake Geary Richard S EVP, Chief Development Officer Sold on a plan $126.09K 3 Nov 2025 · at $75.05 · 2.7% of stake Geary Richard S EVP, Chief Development Officer Sold on a plan $120.09K 5 Nov 2025 · at $75.01 · 2.6% of stake Birchler Brian EVP, Corp and Development Ops Sold on a plan $609.38K 6 Nov 2025 · at $76.17 · 14.1% of stake Geary Richard S EVP, Chief Development Officer Sold on a plan $2.50M 6 Nov 2025 · at $75.72 · 35.6% of stake HERMAN JOAN E Director Sold at will $3.17M 19 Nov 2025 · at $72.13 · 48.8% of stake KLEIN JOSEPH III Director Sold on a plan $960.00K 25 Nov 2025 · at $80.00 · 100% of stake Devers Shannon L. EVP, Chief Human Resources Ofc Sold on a plan $1.36M 25 Nov 2025 · at $80.91 · 49.0% of stake WENDER JOSEPH H Director Sold on a plan $2.26M 1 Dec 2025 · at $80.82 · 43.7% of stake Swayze Eric EVP Research Sold on a plan $1.86M 2 Jan 2026 · at $79.12 · 43.5% of stake Devers Shannon L. EVP, Chief Human Resources Ofc Sold on a plan $3.76M 7 Jan 2026 · at $85.08 · 71.6% of stake Swayze Eric EVP Research Sold at will $3.72K 16 Jan 2026 · at $75.97 · 13.4% of stake Baroldi Joseph EVP, Chief Business Officer Sold at will $87.07K 16 Jan 2026 · at $75.78 · 19.4% of stake Jenne Kyle EVP, Chf GL Pdt Str Ofcr Sold at will $138.48K 16 Jan 2026 · at $75.96 · 10.0% of stake Kordasiewicz Holly B. EVP, Chief Development Officer Sold at will $313.31K 16 Jan 2026 · at $75.66 · 22.0% of stake Baroldi Joseph EVP, Chief Business Officer Sold at will $523.21K 16 Jan 2026 · at $75.75 · 14.6% of stake Devers Shannon L. EVP, Chief Human Resources Ofc Sold at will $634.41K 16 Jan 2026 · at $75.95 · 24.0% of stake Birchler Brian EVP, Corp and Development Ops Sold at will $636.93K 16 Jan 2026 · at $75.11 · 12.3% of stake BENNETT C FRANK EVP, Chief Scientific Officer Sold at will $674.62K 16 Jan 2026 · at $75.15 · 8.7% of stake O'NEIL PATRICK R. EVP CLO & General Counsel Sold at will $697.05K 16 Jan 2026 · at $75.84 · 12.2% of stake Schneider Eugene EVP, Chf Clinical Develop Ofcr Sold at will $703.14K 16 Jan 2026 · at $75.59 · 12.7% of stake Swayze Eric EVP Research Sold at will $744.66K 16 Jan 2026 · at $75.34 · 19.1% of stake HOUGEN ELIZABETH L EVP, Finance & CFO Sold at will $971.99K 16 Jan 2026 · at $75.22 · 9.3% of stake Monia Brett P Chief Executive Officer Sold at will $3.29M 16 Jan 2026 · at $74.82 · 16.4% of stake Devers Shannon L. EVP, Chief Human Resources Ofc Sold on a plan $323.49K 22 Jan 2026 · at $81.34 · 15.0% of stake Baroldi Joseph EVP, Chief Business Officer Sold at will $439.36K 30 Jan 2026 · at $82.96 · 10.4% of stake BENNETT C FRANK EVP, Chief Scientific Officer Sold at will $488.14K 30 Jan 2026 · at $82.95 · 5.5% of stake Swayze Eric EVP Research Sold at will $512.45K 30 Jan 2026 · at $82.93 · 11.5% of stake Birchler Brian EVP, Corp and Development Ops Sold at will $513.05K 30 Jan 2026 · at $83.03 · 8.5% of stake Schneider Eugene EVP, Chf Clinical Develop Ofcr Sold at will $515.63K 30 Jan 2026 · at $83.45 · 8.1% of stake O'NEIL PATRICK R. EVP CLO & General Counsel Sold at will $516.15K 30 Jan 2026 · at $83.53 · 7.9% of stake HOUGEN ELIZABETH L EVP, Finance & CFO Sold at will $581.70K 30 Jan 2026 · at $83.24 · 5.0% of stake Monia Brett P Chief Executive Officer Sold at will $5.21M 30 Jan 2026 · at $82.72 · 18.2% of stake BENNETT C FRANK EVP, Chief Scientific Officer Sold on a plan $7.06M 2 Feb 2026 · at $82.93 · 51.5% of stake Monia Brett P Chief Executive Officer Sold on a plan $2.52M 6 Feb 2026 · at $85.79 · 10.4% of stake PARSHALL B LYNNE Director Sold on a plan $413.59K 11 Feb 2026 · at $82.72 · 8.2% of stake Swayze Eric EVP Research Sold on a plan $1.28M 13 Feb 2026 · at $81.76 · 32.8% of stake LOSCALZO JOSEPH Director Sold on a plan $66.83K 3 Mar 2026 · at $80.33 · 2.2% of stake Baroldi Joseph EVP, Chief Business Officer Sold on a plan $170.81K 3 Mar 2026 · at $80.42 · 32.8% of stake Baroldi Joseph EVP, Chief Business Officer Sold on a plan $325.06K 3 Mar 2026 · at $79.36 · 9.0% of stake Devers Shannon L. EVP, Chief Human Resources Ofc Sold on a plan $1.60M 3 Mar 2026 · at $79.40 · 47.1% of stake KLEIN JOSEPH III Director Sold on a plan $1.70M 3 Mar 2026 · at $79.51 · 65.9% of stake Diaz Allene M. Director Sold on a plan $4.35M 3 Mar 2026 · at $79.35 · 93.5% of stake BENNETT C FRANK EVP, Chief Scientific Officer Sold on a plan $6.74M 3 Mar 2026 · at $79.23 · 51.4% of stake LOSCALZO JOSEPH Director Sold on a plan $16.00K 4 Mar 2026 · at $80.00 · 0.5% of stake Baroldi Joseph EVP, Chief Business Officer Sold on a plan $35.12K 4 Mar 2026 · at $80.00 · 9.2% of stake O'NEIL PATRICK R. EVP CLO & General Counsel Sold on a plan $763.66K 9 Mar 2026 · at $75.25 · 14.0% of stake Monia Brett P Chief Executive Officer Sold on a plan $9.53M 9 Mar 2026 · at $75.20 · 34.3% of stake Monia Brett P Chief Executive Officer Sold on a plan $2.59M 10 Mar 2026 · at $75.92 · 12.3% of stake Jenne Kyle EVP, Chf GL Pdt Str Ofcr Sold on a plan $2.83M 10 Mar 2026 · at $75.85 · 76.1% of stake HOUGEN ELIZABETH L EVP, Finance & CFO Sold on a plan $15.57M 16 Mar 2026 · at $72.40 · 69.8% of stake HOUGEN ELIZABETH L EVP, Finance & CFO Sold on a plan $744.66K 17 Mar 2026 · at $73.21 · 11.0% of stake Schneider Eugene EVP, Chf Clinical Develop Ofcr Sold on a plan $412.49K 19 Mar 2026 · at $70.97 · 8.3% of stake KLEIN JOSEPH III Director Sold on a plan $1.69M 1 Apr 2026 · at $75.55 · 67.0% of stake Devers Shannon L. EVP, Chief Human Resources Ofc Sold on a plan $458.61K 2 Apr 2026 · at $74.05 · 27.5% of stake PARSHALL B LYNNE Director Sold on a plan $381.37K 15 Apr 2026 · at $76.27 · 8.9% of stake Birchler Brian EVP, Corp and Development Ops Sold at will $73.02K 16 Apr 2026 · at $75.04 · 1.4% of stake Jenne Kyle EVP, Chf GL Pdt Str Ofcr Sold at will $368.49K 16 Apr 2026 · at $75.17 · 17.1% of stake Baroldi Joseph EVP, Chief Business Officer Sold at will $418.95K 16 Apr 2026 · at $74.56 · 10.8% of stake Baroldi Joseph EVP, Chief Business Officer Sold on a plan $116.73K 28 Apr 2026 · at $71.79 · 3.5% of stake KLEIN JOSEPH III Director Sold on a plan $743.24K 1 May 2026 · at $73.51 · 47.9% of stake LOSCALZO JOSEPH Director Sold on a plan $5.80M 4 May 2026 · at $75.06 · 68.0% of stake Monia Brett P Chief Executive Officer Sold on a plan $102.67K 13 May 2026 · at $78.01 · 0.5% of stake Monia Brett P Chief Executive Officer Sold on a plan $253.35K 14 May 2026 · at $78.68 · 1.3% of stake BERTHELSEN SPENCER R Director Sold on a plan $605.36K 1 Jun 2026 · at $75.67 · 4.9% of stake Kordasiewicz Holly B. EVP, Chief Development Officer Sold on a plan $4.47M 12 Jun 2026 · at $73.41 · 73.0% of stake BERTHELSEN SPENCER R Director Sold on a plan $587.92K 15 Jun 2026 · at $73.49 · 4.9% of stake Monia Brett P Chief Executive Officer Sold on a plan $1.14M 24 Jun 2026 · at $78.41 · 5.6% of stake Swayze Eric EVP Research Sold on a plan $839.49K 25 Jun 2026 · at $79.18 · 32.8% of stake Monia Brett P Chief Executive Officer Sold on a plan $1.65M 25 Jun 2026 · at $78.49 · 7.9% of stake O'NEIL PATRICK R. EVP CLO & General Counsel Sold on a plan $245.52K 26 Jun 2026 · at $80.00 · 4.8% of stake Baroldi Joseph EVP, Chief Business Officer Sold on a plan $451.70K 26 Jun 2026 · at $80.16 · 54.7% of stake Schneider Eugene EVP, Chf Clinical Develop Ofcr Sold on a plan $2.11M 26 Jun 2026 · at $81.05 · 25.2% of stake Monia Brett P Chief Executive Officer Sold on a plan $4.03M 26 Jun 2026 · at $80.59 · 16.9% of stake KLEIN JOSEPH III Director Sold on a plan $910.42K 1 Jul 2026 · at $79.04 · 51.1% of stake Kordasiewicz Holly B. EVP, Chief Development Officer Sold on a plan $30.52K 7 Jul 2026 · at $84.30 · 1.6% of stake BENNETT C FRANK EVP, Chief Scientific Officer Sold on a plan $462.69K 7 Jul 2026 · at $83.58 · 6.9% of stake Diaz Allene M. Director Sold on a plan $863.64K 7 Jul 2026 · at $85.42 · 72.6% of stake BENNETT C FRANK EVP, Chief Scientific Officer Sold on a plan $1.28M 7 Jul 2026 · at $85.46 · 100% of stake Hayden Michael R Director Bought $800.70K 30 Jul 2026 · at $53.38 · 375% of stake Hayden Michael R Director Bought $258.00K 31 Jul 2026 · at $51.60 · 26.3% of stake
2 buys26 sales at will62 planned sales

Key numbers

Fiscal year 2025, ended 31 Dec 2025, as filed
Revenue
$943.71M
Net income
$381.39M
Free cash flow
$320.03M
Operating margin
-40.5%
Net margin
-40.4%
Return on equity
-78.0%
Return on capital
-13.4%
Debt to equity
3.60
Revenue growth, 1 yr
33.8%
Revenue growth, 5 yr
5.3% a year

Revenue and net income

Fiscal years, as filed with the SEC · point at a year for the detail
729M -444M FY20 Fiscal year 2020 Revenue $729.26M Net income $444.26M Margin -60.9% 810M -29M FY21 Fiscal year 2021 Revenue $810.46M Net income $28.60M Margin -3.5% · growth +11.1% 587M -270M FY22 Fiscal year 2022 Revenue $587.37M Net income $269.72M Margin -45.9% · growth -27.5% 788M -366M FY23 Fiscal year 2023 Revenue $787.65M Net income $366.29M Margin -46.5% · growth +34.1% 705M -454M FY24 Fiscal year 2024 Revenue $705.14M Net income $453.90M Margin -64.4% · growth -10.5% 944M -381M FY25 Fiscal year 2025 Revenue $943.71M Net income $381.39M Margin -40.4% · growth +33.8%
RevenueNet incomeLoss

Latest insider transactions

From Form 4, most recent first
All of them →
DateInsiderTypeValueOf own stake
31 Jul 2026 Hayden Michael R
Director
Bought $258.00K 26.3%
30 Jul 2026 Hayden Michael R
Director
Bought $800.70K 375%
7 Jul 2026 BENNETT C FRANK
EVP, Chief Scientific Officer
Sold on a plan $1.28M 100%
7 Jul 2026 Diaz Allene M.
Director
Sold on a plan $863.64K 72.6%
7 Jul 2026 BENNETT C FRANK
EVP, Chief Scientific Officer
Sold on a plan $462.69K 6.9%
7 Jul 2026 Kordasiewicz Holly B.
EVP, Chief Development Officer
Sold on a plan $30.52K 1.6%