InsiderClue
Stocks · Health care · Biological Products, (No Diagnostic Substances)

Denali Therapeutics Inc.

DNLI Clue Score33
United States Fiscal year ends December CIK 0001714899
$19.45 +4.18% Close, 9 Oct 2026
Alert on the numbers Alert on insider trades
Price $19.45 −58.72% Close, 9 Oct 2026

Closing prices at the end of each trading day, from 8 Dec 2017. Not a live quote. Adjusted for share splits, so the line has no step at a split; dividends are not added back. P/E and P/FCF are the market value over the last full fiscal year's net income or free cash flow, as public on each day, so they step once a year when the annual report comes out. A hatched band marks a stretch with none: a year of net loss, or of cash burnt.

Revenue and profit

What the business sells, and what is left of it. Point at a year for the detail.
RevenueOperating incomeNet income
Fiscal year 2016Revenue0.0Operating income−87.4Net income−86.7Fiscal year 2017Revenue0.0Operating income−90.1Net income−88.2Fiscal year 2018Revenue129.1Operating income−46.4Net income−36.2EPS, diluted−0.39Fiscal year 2019Revenue26.3 −79.6%Operating income−213.2Net income−197.6EPS, diluted−2.07Fiscal year 2020Revenue335.6 +1,174.9%Operating income62.7Net income71.1EPS, diluted0.63Fiscal year 2021Revenue48.7 −85.5%Operating income−295.8Net income−290.6 −508.5%EPS, diluted−2.39 −479.4%Fiscal year 2022Revenue105.1 +115.9%Operating income−340.7Net income−326.0EPS, diluted−2.60Fiscal year 2023Revenue330.5 +214.6%Operating income−196.7Net income−145.2EPS, diluted−1.06Fiscal year 2024Revenue0.0 −100.0%Operating income−487.3Net income−422.8EPS, diluted−2.57Fiscal year 2025Revenue0.0Operating income−555.3Net income−512.5EPS, diluted−2.97
FY2016FY2017FY2018FY2019FY2020FY2021FY2022FY2023FY2024FY2025
Revenue 0.0 0.0 129.1 26.3 335.6 48.7 105.1 330.5 0.0 0.0
Growth −79.6% +1,174.9% −85.5% +115.9% +214.6% −100.0%
Operating income −87.4 −90.1 −46.4 −213.2 62.7 −295.8 −340.7 −196.7 −487.3 −555.3
Net income −86.7 −88.2 −36.2 −197.6 71.1 −290.6 −326.0 −145.2 −422.8 −512.5
Growth −508.5%
EPS, diluted n/a n/a −0.39 −2.07 0.63 −2.39 −2.60 −1.06 −2.57 −2.97
Growth −479.4%

Margins

How much of each dollar of revenue it keeps. Point at a year for the detail.
Operating marginNet margin
Fiscal year 2016Fiscal year 2017Fiscal year 2018Operating margin−35.9%Net margin−28.1%Free cash flow margin36.2%Fiscal year 2019Operating margin−810.0%Net margin−750.8%Free cash flow margin−644.0%Fiscal year 2020Operating margin18.7%Net margin21.2%Free cash flow margin123.1%Fiscal year 2021Operating margin−607.8%Net margin−597.2%Free cash flow margin−451.9%Fiscal year 2022Operating margin−324.3%Net margin−310.3%Free cash flow margin−249.9%Fiscal year 2023Operating margin−59.5%Net margin−43.9%Free cash flow margin−112.2%Fiscal year 2024Fiscal year 2025
FY2016FY2017FY2018FY2019FY2020FY2021FY2022FY2023FY2024FY2025
Operating margin n/a n/a −35.9% −810.0% 18.7% −607.8% −324.3% −59.5% n/a n/a
Net margin n/a n/a −28.1% −750.8% 21.2% −597.2% −310.3% −43.9% n/a n/a
Free cash flow margin n/a n/a 36.2% −644.0% 123.1% −451.9% −249.9% −112.2% n/a n/a

Cash flow

The cash the business makes, what it reinvests, and what it hands back. Point at a year for the detail.
Operating cash flowCapital expenditureFree cash flow
Fiscal year 2016Operating cash flow−71.9Capital expenditure−6.1Free cash flow−78.0Fiscal year 2017Operating cash flow−76.6Capital expenditure−2.9Free cash flow−79.5Fiscal year 2018Operating cash flow50.1Capital expenditure−3.4Free cash flow46.7Fiscal year 2019Operating cash flow−151.6Capital expenditure−17.9Free cash flow−169.5 −462.8%Fiscal year 2020Operating cash flow416.2Capital expenditure−3.1Free cash flow413.1Fiscal year 2021Operating cash flow−211.4Capital expenditure−8.5Free cash flow−219.9 −153.2%Fiscal year 2022Operating cash flow−244.7Capital expenditure−17.8Free cash flow−262.5Fiscal year 2023Operating cash flow−358.0Capital expenditure−12.9Free cash flow−370.9Fiscal year 2024Operating cash flow−347.7Capital expenditure−15.9Free cash flow−363.6Fiscal year 2025Operating cash flow−412.6Capital expenditure−9.5Free cash flow−422.1
FY2016FY2017FY2018FY2019FY2020FY2021FY2022FY2023FY2024FY2025
Operating cash flow −71.9 −76.6 50.1 −151.6 416.2 −211.4 −244.7 −358.0 −347.7 −412.6
Capital expenditure −6.1 −2.9 −3.4 −17.9 −3.1 −8.5 −17.8 −12.9 −15.9 −9.5
Free cash flow −78.0 −79.5 46.7 −169.5 413.1 −219.9 −262.5 −370.9 −363.6 −422.1
Growth −462.8% −153.2%

Balance sheet

What it holds against what it owes, at each year end. Point at a year for the detail.
Cash
Fiscal year 2016Cash39.9Shareholders’ equity−94.2Fiscal year 2017Cash218.4Shareholders’ equity465.8Fiscal year 2018Cash77.1Shareholders’ equity546.8Fiscal year 2019Cash79.4Shareholders’ equity394.9Fiscal year 2020Cash507.1Shareholders’ equity1,150.5Fiscal year 2021Cash293.5Shareholders’ equity962.3Fiscal year 2022Cash218.0Shareholders’ equity1,042.4Fiscal year 2023Cash127.1Shareholders’ equity1,031.0Fiscal year 2024Cash175.0Shareholders’ equity1,229.7Fiscal year 2025Cash205.3Shareholders’ equity1,013.8
FY2016FY2017FY2018FY2019FY2020FY2021FY2022FY2023FY2024FY2025
Cash 39.9 218.4 77.1 79.4 507.1 293.5 218.0 127.1 175.0 205.3
Shareholders’ equity −94.2 465.8 546.8 394.9 1,150.5 962.3 1,042.4 1,031.0 1,229.7 1,013.8

In millions of USD, except per-share figures and ratios. Fiscal years, as last filed with the SEC.

Financial statements FY2025 · 10-K

Ratios

Percentages worked out from the filed figures; debt to equity in times. Fiscal years ending December, each column as last filed with the SEC.
Click a line to chart it
Fiscal year FY2016 31 Dec 2016 FY2017 31 Dec 2017 FY2018 31 Dec 2018 FY2019 31 Dec 2019 FY2020 31 Dec 2020 FY2021 31 Dec 2021 FY2022 31 Dec 2022 FY2023 31 Dec 2023 FY2024 31 Dec 2024 FY2025 31 Dec 2025
Margins
n/a n/a −35.9% −810.0% 18.7% −607.8% −324.3% −59.5% n/a n/a
n/a n/a −28.1% −750.8% 21.2% −597.2% −310.3% −43.9% n/a n/a
n/a n/a 36.2% −644.0% 123.1% −451.9% −249.9% −112.2% n/a n/a
Spending
n/a n/a 110.9% 734.7% 63.4% 545.4% 341.4% 128.2% n/a n/a
n/a n/a 25.1% 176.6% 18.0% 162.5% 86.1% 31.3% n/a n/a
n/a n/a 2.6% 68.1% 0.9% 17.5% 17.0% 3.9% n/a n/a
Returns
n/a −18.9% −6.6% −50.0% 6.2% −30.2% −31.3% −14.1% −34.4% −50.6%
n/a −18.1% −5.5% −35.7% 4.4% −20.7% −22.3% −12.6% −30.8% −44.8%
Balance and payout
n/a 4.3% 17.4% 28.6% 28.3% 31.5% 28.6% 10.7% 10.5% 11.5%