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Spyre Therapeutics, Inc.

SYRE Clue Score15
United States Fiscal year ends December CIK 0001636282
$85.69 +7.25% Close, 9 Oct 2026
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Price $85.69 +975.16% Close, 9 Oct 2026

Closing prices at the end of each trading day, from 12 Oct 2016. Not a live quote. Adjusted for share splits, so the line has no step at a split; dividends are not added back.

Revenue and profit

What the business sells, and what is left of it. Point at a year for the detail.
RevenueOperating incomeNet income
Fiscal year 2016Revenue4.6Operating income−21.9Net income−21.7Fiscal year 2017Revenue5.2 +12.5%Operating income−27.7Net income−27.2Fiscal year 2018Revenue3.9 −25.3%Operating income−45.5Net income−44.3Fiscal year 2019Revenue0.0 −100.0%Operating income−80.3Net income−78.3Fiscal year 2020Revenue0.0Operating income−81.5Net income−80.9EPS, diluted−1.52Fiscal year 2021Revenue18.7Operating income−65.6Net income−65.8EPS, diluted−25.02Fiscal year 2022Revenue2.3 −87.6%Operating income−84.8Net income−83.8EPS, diluted−24.86Fiscal year 2023Revenue0.9 −62.0%Operating income−242.3Net income−338.8EPS, diluted13.76Fiscal year 2024Revenue0.0 −100.0%Operating income−208.6Net income−208.0Fiscal year 2025Revenue0.0Operating income−209.6Net income−155.2
FY2016FY2017FY2018FY2019FY2020FY2021FY2022FY2023FY2024FY2025
Revenue 4.6 5.2 3.9 0.0 0.0 18.7 2.3 0.9 0.0 0.0
Growth +12.5% −25.3% −100.0% −87.6% −62.0% −100.0%
Operating income −21.9 −27.7 −45.5 −80.3 −81.5 −65.6 −84.8 −242.3 −208.6 −209.6
Net income −21.7 −27.2 −44.3 −78.3 −80.9 −65.8 −83.8 −338.8 −208.0 −155.2
Growth
EPS, diluted n/a n/a n/a n/a −1.52 −25.02 −24.86 13.76 n/a n/a

Margins

How much of each dollar of revenue it keeps. Point at a year for the detail.
Operating marginNet margin
Fiscal year 2016Operating margin−473.3%Net margin−468.8%Free cash flow margin−411.7%Fiscal year 2017Operating margin−531.7%Net margin−523.3%Free cash flow margin−484.8%Fiscal year 2018Operating margin−1,169.3%Net margin−1,140.6%Free cash flow margin−838.9%Fiscal year 2019Fiscal year 2020Fiscal year 2021Operating margin−350.3%Net margin−351.1%Free cash flow margin−289.7%Fiscal year 2022Operating margin−3,640.2%Net margin−3,598.8%Free cash flow margin−3,442.8%Fiscal year 2023Operating margin−27,348.0%Net margin−38,238.1%Free cash flow margin−11,276.5%Fiscal year 2024Fiscal year 2025
FY2016FY2017FY2018FY2019FY2020FY2021FY2022FY2023FY2024FY2025
Operating margin −473.3% −531.7% −1,169.3% n/a n/a −350.3% −3,640.2% −27,348.0% n/a n/a
Net margin −468.8% −523.3% −1,140.6% n/a n/a −351.1% −3,598.8% −38,238.1% n/a n/a
Free cash flow margin −411.7% −484.8% −838.9% n/a n/a −289.7% −3,442.8% −11,276.5% n/a n/a

Cash flow

The cash the business makes, what it reinvests, and what it hands back. Point at a year for the detail.
Operating cash flowCapital expenditureFree cash flow
Fiscal year 2016Operating cash flow−18.8Capital expenditure−0.2Free cash flow−19.1Fiscal year 2017Operating cash flow−24.6Capital expenditure−0.6Free cash flow−25.2Fiscal year 2018Operating cash flow−32.2Capital expenditure−0.4Free cash flow−32.6Fiscal year 2019Operating cash flow−65.7Capital expenditure−1.5Free cash flow−67.2Fiscal year 2020Operating cash flow−75.8Capital expenditure−4.3Free cash flow−80.1Fiscal year 2021Operating cash flow−53.7Capital expenditure−0.6Free cash flow−54.3Fiscal year 2022Operating cash flow−80.1Capital expenditure−0.0Free cash flow−80.2Fiscal year 2023Operating cash flow−99.9Capital expenditure0.0Free cash flow−99.9Fiscal year 2024Operating cash flow−157.4Capital expenditure0.0Free cash flow−157.4Fiscal year 2025Operating cash flow−169.3
FY2016FY2017FY2018FY2019FY2020FY2021FY2022FY2023FY2024FY2025
Operating cash flow −18.8 −24.6 −32.2 −65.7 −75.8 −53.7 −80.1 −99.9 −157.4 −169.3
Capital expenditure −0.2 −0.6 −0.4 −1.5 −4.3 −0.6 −0.0 0.0 0.0 n/a
Free cash flow −19.1 −25.2 −32.6 −67.2 −80.1 −54.3 −80.2 −99.9 −157.4 n/a
Growth

Balance sheet

What it holds against what it owes, at each year end. Point at a year for the detail.
Cash
Fiscal year 2016Cash47.7Shareholders’ equity63.0Fiscal year 2017Cash12.8Shareholders’ equity50.3Fiscal year 2018Cash22.5Shareholders’ equity67.4Fiscal year 2019Cash19.3Shareholders’ equity60.1Fiscal year 2020Cash90.1Shareholders’ equity139.8Fiscal year 2021Cash15.1Shareholders’ equity83.9Fiscal year 2022Cash34.9Shareholders’ equity50.3Fiscal year 2023Cash188.9Shareholders’ equity184.0Fiscal year 2024Cash89.4Shareholders’ equity517.8Fiscal year 2025Cash85.7Shareholders’ equity715.2
FY2016FY2017FY2018FY2019FY2020FY2021FY2022FY2023FY2024FY2025
Cash 47.7 12.8 22.5 19.3 90.1 15.1 34.9 188.9 89.4 85.7
Shareholders’ equity 63.0 50.3 67.4 60.1 139.8 83.9 50.3 184.0 517.8 715.2

In millions of USD, except per-share figures and ratios. Fiscal years, as last filed with the SEC.

Financial statements FY2025 · 10-K

Income statement

In millions of USD, except per-share figures; shares in millions. Fiscal years ending December, each column as last filed with the SEC.
Click a line to chart it
Fiscal year FY2016 31 Dec 2016 FY2017 31 Dec 2017 FY2018 31 Dec 2018 FY2019 31 Dec 2019 FY2020 31 Dec 2020 FY2021† 31 Dec 2021 FY2022 31 Dec 2022 FY2023† 31 Dec 2023 FY2024 31 Dec 2024 FY2025 31 Dec 2025
Revenue and profit
4.6 5.2 3.9 0.0 0.0 18.7 2.3 0.9 0.0 0.0
Growth +12.5% −25.3% −100.0% −87.6% −62.0% −100.0%
18.1 22.8 36.7 64.6 59.6 57.1 58.6 n/a n/a n/a
8.4 10.1 12.6 15.7 21.8 27.3 28.5 39.9 45.8 47.9
−21.9 −27.7 −45.5 −80.3 −81.5 −65.6 −84.8 −242.3 −208.6 −209.6
Growth
n/a n/a n/a −78.3 −80.9 −65.7 −84.0 −338.8 −208.0 −155.2
0.0 0.0 0.0 0.0 0.0 0.1 −0.1 −0.0 0.1 −0.0
−21.7 −27.2 −44.3 −78.3 −80.9 −65.8 −83.8 −338.8 −208.0 −155.2
Growth
Per share
n/a n/a n/a n/a −1.52 −25.02 −24.86 13.76 n/a n/a
n/a n/a n/a n/a −1.52 −25.02 −24.86 13.76 n/a n/a
Growth
n/a n/a n/a n/a 53.4 2.6 3.4 6.9 n/a n/a
n/a n/a n/a n/a 53.4 2.6 3.4 6.9 n/a n/a
Growth −95.1% +28.2% +104.6%

† The diluted share count jumps at 2021 and 2023, so per-share figures either side of that column are not comparable. Usually a split, but the break lands on the restatement boundary rather than on the split date, because every column is that period’s latest filing.

Five years in brief

Worked out from the figures above, not from a press release
  • A net loss in 10 of 10 years on file.