InsiderClue
Stocks · Health care · Pharmaceutical Preparations

Upstream Bio, Inc.

UPB Clue Score38
United States Fiscal year ends December CIK 0002022626
$4.70 +3.30% Close, 9 Oct 2026
Alert on the numbers Alert on insider trades
Price $4.70 −76.25% Close, 9 Oct 2026

Closing prices at the end of each trading day, from 11 Oct 2024. Not a live quote. Adjusted for share splits, so the line has no step at a split; dividends are not added back.

Revenue and profit

What the business sells, and what is left of it. Point at a year for the detail.
RevenueOperating incomeNet income
Fiscal year 2023Revenue2.4Operating income−40.1Net income−20.5EPS, diluted−12.95Fiscal year 2024Revenue2.4 −0.4%Operating income−77.8Net income−62.8EPS, diluted−5.58Fiscal year 2025Revenue2.9 +20.4%Operating income−160.4Net income−143.4EPS, diluted−2.66
FY2023FY2024FY2025
Revenue 2.4 2.4 2.9
Growth −0.4% +20.4%
Operating income −40.1 −77.8 −160.4
Net income −20.5 −62.8 −143.4
Growth
EPS, diluted −12.95 −5.58 −2.66

Margins

How much of each dollar of revenue it keeps. Point at a year for the detail.
Operating marginNet margin
Fiscal year 2023Operating margin−1,685.5%Net margin−862.9%Free cash flow margin−1,599.6%Fiscal year 2024Operating margin−3,281.2%Net margin−2,650.0%Free cash flow margin−2,518.3%Fiscal year 2025Operating margin−5,618.8%Net margin−5,026.0%Free cash flow margin−4,675.5%
FY2023FY2024FY2025
Operating margin −1,685.5% −3,281.2% −5,618.8%
Net margin −862.9% −2,650.0% −5,026.0%
Free cash flow margin −1,599.6% −2,518.3% −4,675.5%

Cash flow

The cash the business makes, what it reinvests, and what it hands back. Point at a year for the detail.
Operating cash flowCapital expenditureFree cash flow
Fiscal year 2023Operating cash flow−37.9Capital expenditure−0.1Free cash flow−38.1Fiscal year 2024Operating cash flow−59.2Capital expenditure−0.5Free cash flow−59.7Fiscal year 2025Operating cash flow−133.3Capital expenditure−0.2Free cash flow−133.4
FY2023FY2024FY2025
Operating cash flow −37.9 −59.2 −133.3
Capital expenditure −0.1 −0.5 −0.2
Free cash flow −38.1 −59.7 −133.4
Growth

Balance sheet

What it holds against what it owes, at each year end. Point at a year for the detail.
Cash
Fiscal year 2023Cash25.8Shareholders’ equity−123.1Fiscal year 2024Cash325.9Shareholders’ equity469.9Fiscal year 2025Cash101.6Shareholders’ equity339.8
FY2023FY2024FY2025
Cash 25.8 325.9 101.6
Shareholders’ equity −123.1 469.9 339.8

In millions of USD, except per-share figures and ratios. Fiscal years, as last filed with the SEC.

Financial statements FY2025 · 10-K

Income statement

In millions of USD, except per-share figures; shares in millions. Fiscal years ending December, each column as last filed with the SEC.
Click a line to chart it
Fiscal year FY2023 31 Dec 2023 FY2024† 31 Dec 2024 FY2025† 31 Dec 2025
Revenue and profit
2.4 2.4 2.9
Growth −0.4% +20.4%
31.8 63.0 136.8
10.7 17.2 26.4
−40.1 −77.8 −160.4
Growth
0.0 0.0 0.0
−20.5 −62.8 −143.4
Growth
Per share
−12.95 −5.58 −2.66
−12.95 −5.58 −2.66
Growth
3.0 13.7 53.9
3.0 13.7 53.9
Growth +363.2% +293.6%

† The diluted share count jumps at 2024 and 2025, so per-share figures either side of that column are not comparable. Usually a split, but the break lands on the restatement boundary rather than on the split date, because every column is that period’s latest filing.

Five years in brief

Worked out from the figures above, not from a press release
  • A net loss in 3 of 3 years on file.