Stocks · Health care · Pharmaceutical Preparations

Upstream Bio, Inc.

UPB Clue Score38
United States Fiscal year ends December CIK 0002022626
4.70
+3.30%
Close, 9 Oct 2026 · USD

Price, with every insider trade on it

Closing prices, 12 months · point at a dot for who traded, or at the line for the close
4.70 on 9 Oct 2026
33 19 5 Oct 2025 Apr 2026 Oct 2026 13 Oct 2025 $20.08 14 Oct 2025 $19.98 15 Oct 2025 $21.69 16 Oct 2025 $22.28 17 Oct 2025 $20.97 20 Oct 2025 $23.05 21 Oct 2025 $22.33 22 Oct 2025 $22.15 23 Oct 2025 $21.13 24 Oct 2025 $21.86 27 Oct 2025 $23.58 28 Oct 2025 $24.84 29 Oct 2025 $24.19 30 Oct 2025 $25.77 31 Oct 2025 $25.85 3 Nov 2025 $25.02 4 Nov 2025 $25.04 5 Nov 2025 $23.97 6 Nov 2025 $23.66 7 Nov 2025 $22.96 10 Nov 2025 $23.50 11 Nov 2025 $23.78 12 Nov 2025 $23.72 13 Nov 2025 $23.34 14 Nov 2025 $24.53 17 Nov 2025 $25.70 18 Nov 2025 $25.56 19 Nov 2025 $24.94 20 Nov 2025 $24.96 21 Nov 2025 $25.55 24 Nov 2025 $26.05 25 Nov 2025 $28.83 26 Nov 2025 $28.00 28 Nov 2025 $28.60 1 Dec 2025 $28.98 2 Dec 2025 $25.01 3 Dec 2025 $26.97 4 Dec 2025 $27.74 5 Dec 2025 $27.75 8 Dec 2025 $28.97 9 Dec 2025 $28.37 10 Dec 2025 $28.67 11 Dec 2025 $27.47 12 Dec 2025 $27.14 15 Dec 2025 $27.20 16 Dec 2025 $29.32 17 Dec 2025 $28.33 18 Dec 2025 $29.86 19 Dec 2025 $29.35 22 Dec 2025 $30.43 23 Dec 2025 $29.21 24 Dec 2025 $30.27 26 Dec 2025 $29.48 29 Dec 2025 $28.83 30 Dec 2025 $27.32 31 Dec 2025 $27.15 2 Jan 2026 $27.07 5 Jan 2026 $26.13 6 Jan 2026 $25.87 7 Jan 2026 $28.08 8 Jan 2026 $27.54 9 Jan 2026 $29.75 12 Jan 2026 $31.66 13 Jan 2026 $32.60 14 Jan 2026 $32.30 15 Jan 2026 $30.90 16 Jan 2026 $31.00 20 Jan 2026 $31.00 21 Jan 2026 $31.59 22 Jan 2026 $31.79 23 Jan 2026 $30.02 26 Jan 2026 $30.16 27 Jan 2026 $32.50 28 Jan 2026 $30.43 29 Jan 2026 $30.94 30 Jan 2026 $31.08 2 Feb 2026 $29.94 3 Feb 2026 $30.79 4 Feb 2026 $29.38 5 Feb 2026 $26.00 6 Feb 2026 $26.20 9 Feb 2026 $26.12 10 Feb 2026 $27.81 11 Feb 2026 $14.69 12 Feb 2026 $12.80 13 Feb 2026 $8.75 17 Feb 2026 $8.33 18 Feb 2026 $8.29 19 Feb 2026 $8.54 20 Feb 2026 $8.08 23 Feb 2026 $8.02 24 Feb 2026 $7.92 25 Feb 2026 $7.74 26 Feb 2026 $7.90 27 Feb 2026 $7.68 2 Mar 2026 $7.70 3 Mar 2026 $7.36 4 Mar 2026 $7.80 5 Mar 2026 $7.67 6 Mar 2026 $7.66 9 Mar 2026 $8.06 10 Mar 2026 $8.12 11 Mar 2026 $9.36 12 Mar 2026 $9.44 13 Mar 2026 $9.23 16 Mar 2026 $9.61 17 Mar 2026 $9.71 18 Mar 2026 $8.67 19 Mar 2026 $8.38 20 Mar 2026 $8.67 23 Mar 2026 $8.45 24 Mar 2026 $8.45 25 Mar 2026 $9.47 26 Mar 2026 $9.79 27 Mar 2026 $8.67 30 Mar 2026 $8.78 31 Mar 2026 $9.00 1 Apr 2026 $9.31 2 Apr 2026 $9.50 6 Apr 2026 $9.72 7 Apr 2026 $9.70 8 Apr 2026 $9.84 9 Apr 2026 $10.42 10 Apr 2026 $10.49 13 Apr 2026 $10.23 14 Apr 2026 $10.34 15 Apr 2026 $9.88 16 Apr 2026 $10.10 17 Apr 2026 $9.99 20 Apr 2026 $9.99 21 Apr 2026 $9.26 22 Apr 2026 $9.64 23 Apr 2026 $9.60 24 Apr 2026 $9.30 27 Apr 2026 $9.29 28 Apr 2026 $9.51 29 Apr 2026 $9.19 30 Apr 2026 $9.18 1 May 2026 $9.40 4 May 2026 $9.31 5 May 2026 $9.12 6 May 2026 $9.19 7 May 2026 $8.99 8 May 2026 $9.09 11 May 2026 $9.11 12 May 2026 $8.95 13 May 2026 $9.36 14 May 2026 $8.79 15 May 2026 $9.09 18 May 2026 $8.51 19 May 2026 $8.03 20 May 2026 $8.41 21 May 2026 $8.46 22 May 2026 $8.37 26 May 2026 $8.21 27 May 2026 $8.26 28 May 2026 $8.32 29 May 2026 $8.36 1 Jun 2026 $8.08 2 Jun 2026 $7.25 3 Jun 2026 $7.63 4 Jun 2026 $7.43 5 Jun 2026 $7.05 8 Jun 2026 $6.45 9 Jun 2026 $6.69 10 Jun 2026 $6.28 11 Jun 2026 $6.38 12 Jun 2026 $6.10 15 Jun 2026 $6.10 16 Jun 2026 $5.92 17 Jun 2026 $6.15 18 Jun 2026 $6.25 22 Jun 2026 $6.30 23 Jun 2026 $6.32 24 Jun 2026 $6.35 25 Jun 2026 $6.36 26 Jun 2026 $6.75 29 Jun 2026 $6.93 30 Jun 2026 $6.92 1 Jul 2026 $7.28 2 Jul 2026 $7.51 6 Jul 2026 $7.40 7 Jul 2026 $7.86 8 Jul 2026 $7.98 9 Jul 2026 $7.81 10 Jul 2026 $7.53 13 Jul 2026 $7.28 14 Jul 2026 $7.14 15 Jul 2026 $7.27 16 Jul 2026 $7.23 17 Jul 2026 $7.01 20 Jul 2026 $6.98 21 Jul 2026 $6.98 22 Jul 2026 $6.59 23 Jul 2026 $6.40 24 Jul 2026 $6.41 27 Jul 2026 $6.40 28 Jul 2026 $6.40 29 Jul 2026 $6.41 30 Jul 2026 $6.57 31 Jul 2026 $6.31 3 Aug 2026 $6.42 4 Aug 2026 $6.79 5 Aug 2026 $6.74 6 Aug 2026 $6.87 7 Aug 2026 $7.25 10 Aug 2026 $7.44 11 Aug 2026 $7.09 12 Aug 2026 $6.91 13 Aug 2026 $6.91 14 Aug 2026 $7.07 17 Aug 2026 $7.14 18 Aug 2026 $6.85 19 Aug 2026 $7.52 20 Aug 2026 $6.85 21 Aug 2026 $6.97 24 Aug 2026 $6.61 25 Aug 2026 $7.18 26 Aug 2026 $7.13 27 Aug 2026 $6.79 28 Aug 2026 $6.69 31 Aug 2026 $6.62 1 Sep 2026 $6.55 2 Sep 2026 $6.48 3 Sep 2026 $6.08 4 Sep 2026 $6.01 8 Sep 2026 $6.19 9 Sep 2026 $5.96 10 Sep 2026 $5.75 11 Sep 2026 $5.73 14 Sep 2026 $5.81 15 Sep 2026 $5.48 16 Sep 2026 $5.33 17 Sep 2026 $5.31 18 Sep 2026 $5.34 21 Sep 2026 $5.37 22 Sep 2026 $5.49 23 Sep 2026 $5.19 24 Sep 2026 $5.17 25 Sep 2026 $5.36 28 Sep 2026 $5.30 29 Sep 2026 $5.19 30 Sep 2026 $5.27 1 Oct 2026 $5.04 2 Oct 2026 $5.04 5 Oct 2026 $4.85 6 Oct 2026 $4.59 7 Oct 2026 $4.61 8 Oct 2026 $4.55 9 Oct 2026 $4.70 Ambrose Allison General Counsel Sold at will $4.41K 16 Mar 2026 · at $9.29 · 2.8% of stake Houghton Adam Chief Business Officer Sold at will $6.49K 16 Mar 2026 · at $9.29 · 2.8% of stake GRAY MICHAEL CFO and COO Sold at will $7.92K 16 Mar 2026 · at $9.29 · 2.8% of stake Deykin Aaron Chief Medical Officer Sold at will $8.31K 16 Mar 2026 · at $9.29 · 2.7% of stake Sutherland Everett Rand Chief Executive Officer Sold at will $19.44K 16 Mar 2026 · at $9.29 · 2.8% of stake Ambrose Allison General Counsel Sold at will $2.91K 16 Jun 2026 · at $6.10 · 2.9% of stake Houghton Adam Chief Business Officer Sold at will $4.27K 16 Jun 2026 · at $6.10 · 2.9% of stake GRAY MICHAEL CFO and COO Sold at will $5.20K 16 Jun 2026 · at $6.10 · 2.9% of stake Deykin Aaron Chief Medical Officer Sold at will $5.46K 16 Jun 2026 · at $6.10 · 2.6% of stake Sutherland Everett Rand Chief Executive Officer Sold at will $12.78K 16 Jun 2026 · at $6.10 · 2.9% of stake Ambrose Allison General Counsel Sold at will $2.66K 16 Sep 2026 · at $5.49 · 3.0% of stake Houghton Adam Chief Business Officer Sold at will $3.84K 16 Sep 2026 · at $5.49 · 3.0% of stake GRAY MICHAEL CFO and COO Sold at will $4.68K 16 Sep 2026 · at $5.49 · 3.0% of stake Deykin Aaron Chief Medical Officer Sold at will $4.91K 16 Sep 2026 · at $5.49 · 2.7% of stake Sutherland Everett Rand Chief Executive Officer Sold at will $11.50K 16 Sep 2026 · at $5.49 · 3.0% of stake
0 buys15 sales at will0 planned sales

Key numbers

Fiscal year 2025, ended 31 Dec 2025, as filed
Revenue
$2.85M
Net income
$143.44M
Free cash flow
$133.44M
Operating margin
-5,618.8%
Net margin
-5,026.0%
Return on equity
-42.2%
Return on capital
-37.3%
Revenue growth, 1 yr
20.4%

Revenue and net income

Fiscal years, as filed with the SEC · point at a year for the detail
2M -21M FY23 Fiscal year 2023 Revenue $2.38M Net income $20.54M Margin -862.9% 2M -63M FY24 Fiscal year 2024 Revenue $2.37M Net income $62.81M Margin -2,650.0% · growth -0.4% 3M -143M FY25 Fiscal year 2025 Revenue $2.85M Net income $143.44M Margin -5,026.0% · growth +20.4%
RevenueNet incomeLoss

Latest insider transactions

From Form 4, most recent first
All of them →
DateInsiderTypeValueOf own stake
16 Sep 2026 Sutherland Everett Rand
Chief Executive Officer
Sold at will $11.50K 3.0%
16 Sep 2026 Deykin Aaron
Chief Medical Officer
Sold at will $4.91K 2.7%
16 Sep 2026 GRAY MICHAEL
CFO and COO
Sold at will $4.68K 3.0%
16 Sep 2026 Houghton Adam
Chief Business Officer
Sold at will $3.84K 3.0%
16 Sep 2026 Ambrose Allison
General Counsel
Sold at will $2.66K 3.0%
16 Jun 2026 Sutherland Everett Rand
Chief Executive Officer
Sold at will $12.78K 2.9%