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Stocks · Health care · Pharmaceutical Preparations

Upstream Bio, Inc.

UPB Clue Score38
United States Fiscal year ends December CIK 0002022626
$4.70 +3.30% Close, 9 Oct 2026
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Price $4.70 −76.25% Close, 9 Oct 2026

Closing prices at the end of each trading day, from 11 Oct 2024. Not a live quote. Adjusted for share splits, so the line has no step at a split; dividends are not added back.

Revenue and profit

What the business sells, and what is left of it. Point at a year for the detail.
RevenueOperating incomeNet income
Fiscal year 2023Revenue2.4Operating income−40.1Net income−20.5EPS, diluted−12.95Fiscal year 2024Revenue2.4 −0.4%Operating income−77.8Net income−62.8EPS, diluted−5.58Fiscal year 2025Revenue2.9 +20.4%Operating income−160.4Net income−143.4EPS, diluted−2.66
FY2023FY2024FY2025
Revenue 2.4 2.4 2.9
Growth −0.4% +20.4%
Operating income −40.1 −77.8 −160.4
Net income −20.5 −62.8 −143.4
Growth
EPS, diluted −12.95 −5.58 −2.66

Margins

How much of each dollar of revenue it keeps. Point at a year for the detail.
Operating marginNet margin
Fiscal year 2023Operating margin−1,685.5%Net margin−862.9%Free cash flow margin−1,599.6%Fiscal year 2024Operating margin−3,281.2%Net margin−2,650.0%Free cash flow margin−2,518.3%Fiscal year 2025Operating margin−5,618.8%Net margin−5,026.0%Free cash flow margin−4,675.5%
FY2023FY2024FY2025
Operating margin −1,685.5% −3,281.2% −5,618.8%
Net margin −862.9% −2,650.0% −5,026.0%
Free cash flow margin −1,599.6% −2,518.3% −4,675.5%

Cash flow

The cash the business makes, what it reinvests, and what it hands back. Point at a year for the detail.
Operating cash flowCapital expenditureFree cash flow
Fiscal year 2023Operating cash flow−37.9Capital expenditure−0.1Free cash flow−38.1Fiscal year 2024Operating cash flow−59.2Capital expenditure−0.5Free cash flow−59.7Fiscal year 2025Operating cash flow−133.3Capital expenditure−0.2Free cash flow−133.4
FY2023FY2024FY2025
Operating cash flow −37.9 −59.2 −133.3
Capital expenditure −0.1 −0.5 −0.2
Free cash flow −38.1 −59.7 −133.4
Growth

Balance sheet

What it holds against what it owes, at each year end. Point at a year for the detail.
Cash
Fiscal year 2023Cash25.8Shareholders’ equity−123.1Fiscal year 2024Cash325.9Shareholders’ equity469.9Fiscal year 2025Cash101.6Shareholders’ equity339.8
FY2023FY2024FY2025
Cash 25.8 325.9 101.6
Shareholders’ equity −123.1 469.9 339.8

In millions of USD, except per-share figures and ratios. Fiscal years, as last filed with the SEC.

Financial statements FY2025 · 10-K

Ratios

Percentages worked out from the filed figures; debt to equity in times. Fiscal years ending December, each column as last filed with the SEC.
Click a line to chart it
Fiscal year FY2023 31 Dec 2023 FY2024 31 Dec 2024 FY2025 31 Dec 2025
Margins
−1,685.5% −3,281.2% −5,618.8%
−862.9% −2,650.0% −5,026.0%
−1,599.6% −2,518.3% −4,675.5%
Spending
1,336.1% 2,656.8% 4,793.5%
449.4% 724.4% 925.3%
6.1% 21.6% 5.8%
Returns
n/a −13.4% −42.2%
−17.5% −13.0% −40.5%
Balance and payout
8.0% 2.5% 4.0%